N,N-二乙基丁烷-1,4-二胺合成路线 （共 11 条）
反应条件
ethanol; sodium durch Reduktion;
参考文献
Whitmore et al.
Journal of the American Chemical Society, 1944 , vol. 66, p. 725,728
反应条件
methanol; ammonia; nickel P=5148.6 Torr; Hydrogenation;
参考文献
Park, Soobong; Hayes, Brittany L.; Marankan, Fatima; Mulhearn, Debbie C.; Wanna, Linda; Mesecar, Andrew D.; Santarsiero, Bernard D.; Johnson, Michael E.; Venton, Duane L.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 6 p. 936 - 953
反应条件
lithium aluminium tetrahydride in diethyl ether T=0 - 20°C; Reduction; 1 h;
参考文献
Seguin, Helene; Gardette, Daniel; Moreau, Marie-France; Madelmont, Jean-Claude; Gramain, Jean-Claude
Synthetic Communications, 1998 , vol. 28, # 22 p. 4257 - 4272
反应条件
hydrazine hydrate in ethanol 8 h; Reflux;
参考文献
Ke, Chenfeng; Liu, Yu; Yang, Cheng; Mori, Tadashi; Inoue, Yoshihisa; Wada, Takehiko
Angewandte Chemie, International Edition, 2009 , vol. 48, # 36 p. 6675 - 6677
Angewandte Chemie, 2009 , vol. 121, # 36 p. 6803 - 6805
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 1 h;
参考文献
Lavrado, Joao; Cabal, Ghislain G.; Prudencio, Miguel; Mota, Maria M.; Gut, Jiri; Rosenthal, Philip J.; Diaz, Cecilia; Guedes, Rita C.; Dos Santos, Daniel J. V. A.; Bichenkovss, Elena; Douglas, Kenneth T.; Moreira, Rui; Paulo, Alexandra
Journal of Medicinal Chemistry, 2011 , vol. 54, # 3 p. 734 - 750
反应条件
1: 58 percent / NaH / tetrahydrofuran / 2 h / 20 °C 2: 77 percent / KOH / ethanol / 12 h / 0 °C 3: 50 percent / 0.25 h / 150 °C / 4 Torr 4: 76 percent / LiAlH4 / diethyl ether / 1 h / 0 - 20 °C View Scheme
参考文献
Seguin, Helene; Gardette, Daniel; Moreau, Marie-France; Madelmont, Jean-Claude; Gramain, Jean-Claude
Synthetic Communications, 1998 , vol. 28, # 22 p. 4257 - 4272
反应条件
1: 50 percent / 0.25 h / 150 °C / 4 Torr 2: 76 percent / LiAlH4 / diethyl ether / 1 h / 0 - 20 °C View Scheme
参考文献
Seguin, Helene; Gardette, Daniel; Moreau, Marie-France; Madelmont, Jean-Claude; Gramain, Jean-Claude
Synthetic Communications, 1998 , vol. 28, # 22 p. 4257 - 4272
反应条件
1: 77 percent / KOH / ethanol / 12 h / 0 °C 2: 50 percent / 0.25 h / 150 °C / 4 Torr 3: 76 percent / LiAlH4 / diethyl ether / 1 h / 0 - 20 °C View Scheme
参考文献
Seguin, Helene; Gardette, Daniel; Moreau, Marie-France; Madelmont, Jean-Claude; Gramain, Jean-Claude
Synthetic Communications, 1998 , vol. 28, # 22 p. 4257 - 4272
参考文献
Utermohlen; Hamilton
Journal of the American Chemical Society, 1941 , vol. 63, p. 156,158
Full Text Show Details
Strukow
Chim.farm.Promysl.Chem.Abstr., 1933 , p. 333
Chim.farm.Promysl.Chem.Abstr., 1934 , p. II 3494
反应条件
aminosulfonic acid
T=140 - 180°C;
参考文献
GILEAD SCIENCES, INC.; WATKINS, William, J.
Patent: WO2006/47507 A2, 2006 ;
Location in patent: Page/Page column 147-148 ;
WO 2006/047507 A2
