6-溴-1,1,4,4-四甲基-1,2,3,4-四氢化萘合成路线 (共 16 条)
反应条件
Yield given. Multistep reaction;
参考文献
Deloux, Laurent; Srebnik, Morris; Sabat, Michal
Journal of Organic Chemistry, 1995 , vol. 60, # 11 p. 3276 - 3277
参考文献
Hoffmann-La Roche Inc.
Patent: US5801253 A1, 1998 ;
反应条件
1: 1.) Li, 2.) ZnCl2, 3.) tetrakis(triphenylphosphine)nickel(0)
2: 77 percent / KOH / ethanol; H2O / 0.17 h / Heating
View Scheme
参考文献
Dawson, Marcia I.; Chan, Rebecca L.-S.; Derdzinski, Krzysztof; Hobbs, Peter D.; Chao, Wan-Ru; Schiff, Leonard J.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 11 p. 1653 - 1656
参考文献
Eustache; Bernardon; Shroot
Tetrahedron Letters, 1988 , vol. 29, # 35 p. 4409 - 4410
反应条件
magnesium; methyl iodide
1) THF, 50-55 deg C, 30 min, 2) THF, -20 deg C to 0 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Dawson; Hobbs; Derdzinski; Chao; Frenking; Loew; Jetten; Napoli; Williams; Sani; Wille Jr.; Schiff
Journal of Medicinal Chemistry, 1989 , vol. 32, # 7 p. 1504 - 1517
参考文献
Hoffmann-La Roche Inc.
Patent: US5801253 A1, 1998 ;