1-(4,4'-二氯二苯甲基)哌嗪合成路线 （共 6 条）
参考文献
Ortho Pharmaceutical Corporation
Patent: US5021574 A1, 1991 ;
反应条件
in acetonitrile T=90°C; 16 h;
参考文献
Song, Kwang-Seop; Lee, Sung-Han; Chun, Hyun Ji; Kim, Jong Yup; Jung, Myung Eun; Ahn, Kwangwoo; Kim, Soo-Un; Kim, Jeongmin; Lee, Jinhwa
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 7 p. 4035 - 4051
反应条件
sodium hydroxide in methanol 72 h; Heating;
参考文献
Younes, S.; Baziard-Mouysset, G.; Saqui-Sannes, G. de; Stigliani, J. L.; Payard, M.; et al.
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 12 p. 943 - 948
反应条件
1: 98 percent / SOCl2 / cyclohexane / 24 h / Heating 2: 19 percent / K2CO3 / tetrahydrofuran / 14 h / Heating 3: 96 percent / 10percent aq. NaOH / methanol / 72 h / Heating View Scheme
参考文献
Weiwer, Michel; Bittker, Joshua A.; Lewis, Timothy A.; Shimada, Kenichi; Yang, Wan Seok; MacPherson, Lawrence; Dandapani, Sivaraman; Palmer, Michelle; Stockwell, Brent R.; Schreiber, Stuart L.; Munoz, Benito
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1822 - 1826
反应条件
1: NaBH4 / methanol 2: 98 percent / SOCl2 / cyclohexane / 24 h / Heating 3: 19 percent / K2CO3 / tetrahydrofuran / 14 h / Heating 4: 96 percent / 10percent aq. NaOH / methanol / 72 h / Heating View Scheme
参考文献
Weiwer, Michel; Bittker, Joshua A.; Lewis, Timothy A.; Shimada, Kenichi; Yang, Wan Seok; MacPherson, Lawrence; Dandapani, Sivaraman; Palmer, Michelle; Stockwell, Brent R.; Schreiber, Stuart L.; Munoz, Benito
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1822 - 1826
反应条件
1: 19 percent / K2CO3 / tetrahydrofuran / 14 h / Heating 2: 96 percent / 10percent aq. NaOH / methanol / 72 h / Heating View Scheme
参考文献
Younes, S.; Baziard-Mouysset, G.; Saqui-Sannes, G. de; Stigliani, J. L.; Payard, M.; et al.
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 12 p. 943 - 948
