N-[(3aS,4R,6S,6aR)-四氢-6-(2-羟基乙氧基)-2,2-二甲基-4H-环戊烯并-1,3-二氧杂环戊烷-4-基]氨基甲酸苯甲酯合成路线 （共 3 条）
反应条件
1: 5 Pd(II)/C(eggshell) / methanol / 1 h / 20 °C 2: triethylamine; sodium iodide / 1,4-dioxane / 7 h / 120 °C 3: sodium nitrite / water; acetic acid; ethyl acetate / 30 °C 4: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h 5: hydrogenchloride; water / methanol / 1 h View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 11 p. 3598 - 3602
反应条件
hydrogen; palladium on activated charcoal in ethanol
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 21 p. 6013 - 6018
反应条件
Multi-step reaction with 5 steps 1.1: N,N-dimethyl-formamide; toluene / 5 h / 110 °C2.1: palladium 10 on activated carbon; hydrogen / methanol / 14 h / 20 °C3.1: N-ethyl-N,N-diisopropylamine / isobutyl methylketone / 2 h / 20 °C4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / -30 °C4.2: 3 h / 20 °C5.1: lithium borohydride / tetrahydrofuran / 5 h / 0 °C
参考文献
Zhang, Hao; Liu, Jun; Zhang, Luyong; Kong, Lingyi; Yao, Hequan; Sun, Hongbin Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 11 p. 3598 - 3602
