N-乙酰基-S-三苯甲基-L-半胱氨酸合成路线 （共 6 条）
反应条件
sodium hydroxide in 1,4-dioxane; water
T=20°C; pH=9 - 10; 12 h;
参考文献
Zheng, Yan; Duanmu, Chuansong; Gao, Yong
Organic Letters, 2006 , vol. 8, # 15 p. 3215 - 3217
反应条件
in N,N-dimethyl-formamide
T=20°C; 20 h; Inert atmosphere;
参考文献
Loukou, Christina; Changenet-Barret, Pascale; Rager, Marie-Noelle; Plaza, Pascal; Martin, Monique M.; Mallet, Jean-Maurice
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 7 p. 2209 - 2218
反应条件
1: 62.2 percent / dimethylformamide / 48 h / 20 °C
2: 60.2 percent / sodium hydroxide / H2O; dioxane / 12 h / 20 °C / pH 9 - 10
View Scheme
参考文献
Zheng, Yan; Duanmu, Chuansong; Gao, Yong
Organic Letters, 2006 , vol. 8, # 15 p. 3215 - 3217
反应条件
(i) BF3-Et2O, AcOH, (ii) aq. NaOAc; Multistep reaction;
参考文献
Zee-Cheng,K.-Y.; Cheng,C.C.
Journal of Medicinal Chemistry, 1970 , vol. 13, p. 414 - 418
反应条件
4-methyl-morpholine; isobutyl chloroformate in ethyl acetate
T=-15 - 20°C; 3.5 h;
参考文献
Oiry, Joel; Puy, Jean-Yves; Imbach, Jean-Louis; Clayette, Pascal; Fretier, Philippe
Patent: US2004/158092 A1, 2004 ;
Location in patent: Page 12 ;
反应条件
4-methyl-morpholine; isobutyl chloroformate in ethyl acetate
T=-15°C; 2.5 h;
参考文献
Oiry, Joel; Puy, Jean-Yves; Imbach, Jean-Louis; Clayette, Pascal; Fretier, Philippe
Patent: US2004/158092 A1, 2004 ;
Location in patent: Page 12 ;
