4-氰基-4-(3,4-二甲氧基苯基)-5-甲基己胺合成路线 （共 7 条）
反应条件
ammonia; potassium iodide in ethanol; water
T=50°C; 120 h;
参考文献
Wang, Cheng; Wang, Tao; Zhou, Nan; Pan, Xiao-Yan; He, Huai-Zhen
Journal of Asian Natural Products Research, 2014 , vol. 16, # 3 p. 304 - 311
反应条件
hydrazine hydrate in tetrahydrofuran; ethanol
3 h; Ambient temperature;
参考文献
Teodori, Elisabetta; Dei, Silvia; Quidu, Patricia; Budriesi, Roberta; Chiarini, Alberto; Garnier-Suillerot, Arlette; Gualtieri, Fulvio; Manetti, Dina; Romanelli, Maria Novella; Scapecchi, Serena
Journal of Medicinal Chemistry, 1999 , vol. 42, # 10 p. 1687 - 1697
反应条件
1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 2 h, 2.) THF, hexane, from -78 deg C to RT
2: 84 percent / 18-crown-6 / toluene / 6 h / Heating
3: 84 percent / hydrazine hydrate / tetrahydrofuran; ethanol / 3 h / Ambient temperature
View Scheme
参考文献
Teodori, Elisabetta; Dei, Silvia; Quidu, Patricia; Budriesi, Roberta; Chiarini, Alberto; Garnier-Suillerot, Arlette; Gualtieri, Fulvio; Manetti, Dina; Romanelli, Maria Novella; Scapecchi, Serena
Journal of Medicinal Chemistry, 1999 , vol. 42, # 10 p. 1687 - 1697
反应条件
1: 84 percent / 18-crown-6 / toluene / 6 h / Heating
2: 84 percent / hydrazine hydrate / tetrahydrofuran; ethanol / 3 h / Ambient temperature
View Scheme
参考文献
Teodori, Elisabetta; Dei, Silvia; Quidu, Patricia; Budriesi, Roberta; Chiarini, Alberto; Garnier-Suillerot, Arlette; Gualtieri, Fulvio; Manetti, Dina; Romanelli, Maria Novella; Scapecchi, Serena
Journal of Medicinal Chemistry, 1999 , vol. 42, # 10 p. 1687 - 1697
反应条件
NADPH in water; dimethyl sulfoxide
T=37°C; 1 h; Microbiological reaction;
参考文献
Rousu, Timo; Herttuainen, Jukka; Tolonen, Ari
Rapid Communications in Mass Spectrometry, 2010 , vol. 24, # 7 p. 939 - 957
反应条件
1.1: sodium hydroxide / water; dimethyl sulfoxide / 48 h / 20 °C
2.1: sodium amide / toluene / 2 h / |Reflux; |Inert atmosphere
2.2: 48 h / 50 °C / |Reflux; |Inert atmosphere
3.1: ammonia; potassium iodide / water; ethanol / 120 h / 50 °C
View Scheme
参考文献
Wang, Cheng; Wang, Tao; Zhou, Nan; Pan, Xiao-Yan; He, Huai-Zhen
Journal of Asian Natural Products Research, 2014 , vol. 16, # 3 p. 304 - 311
反应条件
cytochrome P450 BM3 chimera variant 22313333
T=37°C; 1 h; aq. phosphate bufferEnzymatic reaction;
参考文献
Sawayama, Andrew M.; Chen, Michael M. Y.; Kulanthaivel, Palaniappan; Kuo, Ming-Shang; Hemmerle, Horst; Arnold, Frances H.
Chemistry - A European Journal, 2009 , vol. 15, # 43 p. 11723 - 11729
