1,3-二甲基-5-吡唑酮合成路线 （共 36 条）
反应条件
1: 72 percent / triethylamine / benzene
2: 29 percent / phosphoryl chloride / 2 h / Heating
3: 92 percent / NaOH / ethanol; H2O / 2 h / Heating
4: 70 percent / conc. H2SO4 / 48 h / Heating
View Scheme
参考文献
Huppatz
Australian Journal of Chemistry, 1983 , vol. 36, # 1 p. 135 - 147
反应条件
T=150°C; at 260 degC; Product distributionMechanism;
参考文献
Tomasik, Danuta; Tomasik, Piotr; Abramovitch, Rudolph A.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1539 - 1543
反应条件
T=150°C; at 260 degC; Product distributionMechanism;
参考文献
Tomasik, Danuta; Tomasik, Piotr; Abramovitch, Rudolph A.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1539 - 1543
参考文献
Nam; Grandberg
Chemistry of Heterocyclic Compounds, 2006 , vol. 42, # 3 p. 326 - 330
反应条件
1: triethylamine / dichloromethane / |Reflux
2: potassium carbonate / 1,4-dioxane / |Reflux
View Scheme
参考文献
Wang, Bao-Lei; Li, Qing-Nan; Zhan, Yi-Zhou; Xiong, Li-Xia; Yu, Shu-Jing; Li, Zheng-Ming
Phosphorus, Sulfur and Silicon and the Related Elements, 2014 , vol. 189, # 4 p. 483 - 491
反应条件
calcium hydroxide powder in 1,4-dioxane
0.5 h; Heating;
参考文献
Wise, Lawrence D.; Butler, Donald E.; DeWald, Horace A.; Lustgarten, David M.; Pattison, Ian C.; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 10 p. 1807 - 1812
反应条件
calcium hydroxide powder in 1,4-dioxane
Heating;
参考文献
Wise, Lawrence D.; Butler, Donald E.; DeWald, Horace A.; Lustgarten, David M.; Pattison, Ian C.; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 10 p. 1807 - 1812
反应条件
calcium hydroxide powder in 1,4-dioxane
Heating;
参考文献
Wise, Lawrence D.; Butler, Donald E.; DeWald, Horace A.; Lustgarten, David M.; Pattison, Ian C.; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 10 p. 1807 - 1812
反应条件
calcium hydroxide powder in 1,4-dioxane
Heating;
参考文献
Wise, Lawrence D.; Butler, Donald E.; DeWald, Horace A.; Lustgarten, David M.; Pattison, Ian C.; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 10 p. 1807 - 1812
反应条件
1: triethylamine / dichloromethane / |Reflux
2: potassium carbonate / 1,4-dioxane / |Reflux
3: trichlorophosphate / 6 h / |Reflux
View Scheme
参考文献
Wang, Bao-Lei; Li, Qing-Nan; Zhan, Yi-Zhou; Xiong, Li-Xia; Yu, Shu-Jing; Li, Zheng-Ming
Phosphorus, Sulfur and Silicon and the Related Elements, 2014 , vol. 189, # 4 p. 483 - 491
