2,3-二氢-1,4-苯并二噁英-5-甲醇合成路线 （共 5 条）
反应条件
sodium hydroxide; sodium tetrahydroborate in methanol T=0 - 20°C;
参考文献
Deveau, Amy Morin; Macdonald, Timothy L.
Tetrahedron Letters, 2004 , vol. 45, # 4 p. 803 - 807
反应条件
sodium hydroxide in diethyl ether; water
参考文献
H. Lundbeck A/S
Patent: US2002/32205 A1, 2002 ;
反应条件
1: With caesium carbonate in DMF (N,N-dimethyl-formamide) 2 h; Heating / reflux; 2: With sodium tetrahydroborate in DMF (N,N-dimethyl-formamide); ethanol T=20°C; 1 h; Product distribution / selectivity;
参考文献
ELI LILLY AND COMPANY
Patent: WO2003/76442 A1, 2003 ;
Location in patent: Page/Page column 49; 63-64 ;
WO 03/076442 A1
反应条件
1: 96 percent / Cs2CO3 / dimethylformamide / 2 h / 110 °C 2: 88 percent / sodium borohydride; aq.NaOH / methanol / 0 - 20 °C View Scheme
参考文献
Deveau, Amy Morin; Macdonald, Timothy L.
Tetrahedron Letters, 2004 , vol. 45, # 4 p. 803 - 807
反应条件
manganese(IV) oxide in tetrahydrofuran T=20 - 60°C; 24 h;
参考文献
Allergan, Inc.
Patent: US2006/69144 A1, 2006 ;
Location in patent: Page/Page column 19-20 ;
US 20060069144 A1
