2-甲氧基-4-氨基苯甲酸甲酯合成路线 （共 39 条）
反应条件
diethyl ether; ethanol
参考文献
Hueckel; Janecka
Archiv der Pharmazie (Weinheim, Germany), 1951 , vol. 284, p. 341,346
反应条件
lithium hydride 1.) THF, RT, 15 min, 2.) THF, 65 deg C, 1 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Knoelker, Hans-Joachim; Bauermeister, Michael
Journal of the Indian Chemical Society, 1994 , vol. 71, # 6-8 p. 345 - 354
反应条件
1: With sodium methylate in methanol T=40°C; 2: With sodium tetrahydroborate in methanol T=20 - 50°C; 8 h;
参考文献
7TM PHARMA A/S; LITTLE, Paul Brian
Patent: WO2004/48319 A1, 2004 ;
Location in patent: Page 31-32 ;
WO 2004/048319 A1
反应条件
1: With paraformaldehyde in methanol T=40°C; 2: With sodium tetrahydroborate in methanol T=20 - 50°C; 8 h;
参考文献
7TM PHARMA A/S
Patent: WO2003/87045 A1, 2003 ;
Location in patent: Page/Page column 55-56 ;
WO 03/087045 A1
反应条件
1: H2O / 1.) room temp., 30 min., 2.) 60-70 deg C, 1 h 2: aq. sodium hypochlorite / 1 h 3: 1.) glacial acetic acid, 2.) NaOH / 1.) 90-95 deg C, 4 h, 2.) water, heating View Scheme
参考文献
Pakula; Butkiewicz; Trojanowska; Ruszczak
Archiv der Pharmazie, 1980 , vol. 313, # 4 p. 297 - 300
反应条件
in ethanol T=50°C; 2 h;
参考文献
Pham, Tien Q.; Greguric, Ivan; Liu, Xiang; Berghofer, Paula; Ballantyne, Patrice; Chapman, Janette; Mattner, Filomena; Dikic, Branko; Jackson, Timothy; Loc'h, Christian; Katsifis, Andrew
Journal of Medicinal Chemistry, 2007 , vol. 50, # 15 p. 3561 - 3572
反应条件
1: ethanol / 2 h / 60 - 65 °C 2: nitric acid; acetic anhydride / 0.17 h / -10 - 0 °C / Inert atmosphere View Scheme
参考文献
PETER MACCALLUM CANCER INSTITUTE; MARTIN, Roger, Francis; WHITE, Jonathan; LOBACHEVSKY, Pavel; WINKLER, David; SKENE, Colin; MARCUCCIO, Sebastian
Patent: WO2011/123890 A1, 2011 ;
反应条件
1: H2O / 1.) room temp., 30 min., 2.) 60-70 deg C, 1 h 2: aq. sodium hypochlorite / 1 h View Scheme
参考文献
Pakula; Butkiewicz; Trojanowska; Ruszczak
Archiv der Pharmazie, 1980 , vol. 313, # 4 p. 297 - 300
反应条件
1: 4-amino-2-methoxy-benzoic acid methyl ester With hydrogenchloride; sodium nitrite in water T=0°C; 0.333333 h; 2: With tin(ll) chloride in water T=0°C; 1.5 h; 3: malonaldehyde bis(dimethyl acetal); ethanol in ethanol Heating / reflux;
参考文献
SB PHARMCO PUERTO RICO INC; NEUROCRINE BIOSCIENCES INC
Patent: WO2005/63756 A1, 2005 ;
Location in patent: Page/Page column 19 ;
WO 2005/063756 A1
反应条件
potassium iodide; iodine; sodium nitrite in hydrogenchloride; water; ethyl acetate
参考文献
Wyeth
Patent: EP1000062 B1, 2004 ;
Location in patent: Page 55 ;
