2-甲氧基-4-氨基苯甲酸甲酯合成路线 （共 39 条）
反应条件
N-chloro-succinimide in acetonitrile Chlorination; 1 h; Heating;
参考文献
Ehrenkaufer, Richard L.; Scripko, James G.; Hoffman, Patricia L.
Organic Preparations and Procedures International, 1992 , vol. 24, # 1 p. 64 - 66
反应条件
1.1: bromine / methanol / 5 - 15 °C / Industry scale 2.1: sodium sulfide / water; acetone / 5 - 15 °C / Industry scale 3.1: sodium hydroxide; water / methanol / 65 °C / Industry scale 3.2: 5 - 10 °C / pH 4 - 4.5 / Industry scale 4.1: dihydrogen peroxide / sodium tungstate / water; methanol / 5 h / 20 - 30 °C View Scheme
参考文献
LUPIN LIMITED; PAGHDAR, Dinesh, Jayntibhai; KOLEKAR, Mahesh, Ramkumar; DESHPANDE, Tushar, Nandkumar; PATIL, Suryaprakash, Pandurang; CHAVAN, Yuvraj, Atmaram; RAY, Purna, Chandra; SINGH, Girij, Pal
Patent: WO2011/158084 A1, 2011 ;
反应条件
1: 74 percent / N-chlorosuccinimide / acetonitrile / 1 h / Heating 2: 86 percent / aq. KOH View Scheme
参考文献
Ehrenkaufer, Richard L.; Scripko, James G.; Hoffman, Patricia L.
Organic Preparations and Procedures International, 1992 , vol. 24, # 1 p. 64 - 66
反应条件
1.1: bromine / methanol / 5 - 15 °C / Industry scale 2.1: sodium sulfide / water; acetone / 5 - 15 °C / Industry scale 3.1: sodium hydroxide; water / methanol / 65 °C / Industry scale 3.2: 5 - 10 °C / pH 4 - 4.5 / Industry scale 4.1: dihydrogen peroxide / sodium tungstate / water; methanol / 5 h / 20 - 30 °C 5.1: chloroformic acid ethyl ester; triethylamine / acetone / 0 - 30 °C View Scheme
参考文献
LUPIN LIMITED; PAGHDAR, Dinesh, Jayntibhai; KOLEKAR, Mahesh, Ramkumar; DESHPANDE, Tushar, Nandkumar; PATIL, Suryaprakash, Pandurang; CHAVAN, Yuvraj, Atmaram; RAY, Purna, Chandra; SINGH, Girij, Pal
Patent: WO2011/158084 A1, 2011 ;
反应条件
bromine in methanol T=5 - 15°C; Industry scale;
参考文献
LUPIN LIMITED; PAGHDAR, Dinesh, Jayntibhai; KOLEKAR, Mahesh, Ramkumar; DESHPANDE, Tushar, Nandkumar; PATIL, Suryaprakash, Pandurang; CHAVAN, Yuvraj, Atmaram; RAY, Purna, Chandra; SINGH, Girij, Pal
Patent: WO2011/158084 A1, 2011 ;
Location in patent: Page/Page column 11 ;
反应条件
bromine; acetic acid T=20°C;
参考文献
DECODE GENETICS EHF
Patent: US2009/130076 A1, 2009 ;
Location in patent: Page/Page column 26; 27 ;
US 20090130076 A1
反应条件
1.1: water; methanol / 20 °C / Reflux 1.2: 3 h / Reflux 2.1: hydrogenchloride; water / 7 h / 75 - 80 °C 3.1: potassium carbonate / methanol / 24 h / 50 - 55 °C 3.2: 2 h / 20 - 55 °C / pH 3 View Scheme
参考文献
MILLENNIUM PHARMACEUTICALS, INC.; ARMITAGE, Ian; COOPER, Martin, I.; EDDLESTON, Mark, D.; FAIBER, Neil, C.; MCCUBBIN, Quentin, J.; WATT, Stephen, W.
Patent: WO2011/103089 A1, 2011 ;
WO 2011/103089 A1
反应条件
1: 89 percent / ethanol / 2 h / 50 °C 2: KOH / methanol; H2O / 2 h / Heating 3: 10.2 g / acetic acid / 2 h / 50 °C 4: thionyl chloride / tetrahydrofuran / 2 h / Heating 5: 1.2 g / triethylamine / tetrahydrofuran / 2 h View Scheme
参考文献
Eisenhut; Hull; Mohammed; Mier; Lay; Just; Gorgas; Lehmann; Haberkorn
Journal of Medicinal Chemistry, 2000 , vol. 43, # 21 p. 3913 - 3922
反应条件
1: 89 percent / ethanol / 2 h / 50 °C 2: 77 percent / iodine monochloride; acetic acid / 6 h / 50 °C 3: KOH / methanol; H2O / 2 h / Heating View Scheme
参考文献
Chumpradit, S.; Choi, S. R.; Zhuang, Z.-P.; Kung, H. F.
Journal of Labelled Compounds and Radiopharmaceuticals, 2001 , vol. 44, p. S225 - S227
反应条件
potassium iodide; sulfuric acid; iodine; sodium nitrite in water
参考文献
Wyeth
Patent: US2003/55047 A1, 2003 ;
US 20030055047 A1
