甲基O-苄基-N-{[(2-甲基-2-丙基)氧基]羰基}-L-酪氨酸酯合成路线 （共 6 条）
反应条件
1: LiAlH4 / tetrahydrofuran / 1 h / 0 °C 2: 90 percent / pyridine / Ambient temperature 3: 23 percent / aq. K2S2O8, aq. CuSO4 / acetonitrile / 1.67 h / Heating View Scheme
参考文献
Kawamine; Takeuchi; Miyashita; Irie; Shimamoto; Ohfune
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 12 p. 3170 - 3171
反应条件
hydrogen; palladium on activated charcoal in methanol T=20°C; Hydrogenolysis; 2 h;
参考文献
Sajiki, Hironao; Hirota, Kosaku
Chemical and Pharmaceutical Bulletin, 2003 , vol. 51, # 3 p. 320 - 324
反应条件
1: chloroacetic acid With lithium diisopropyl amide in tetrahydrofuran; hexane T=-77°C; Metallation; 0.25 h; 2: N-Boc-L-tyrosine(OBn) methyl ester in tetrahydrofuran; hexane T=-15°C; Claisen condensation; 0.166667 h;
参考文献
Wang, Xuebao; Thottathil, John K.; Polniaszek, Richard P.
Synlett, 2000 , # 6 p. 902 - 904
反应条件
sodium tetrahydroborate; lithium iodide in tetrahydrofuran
2 h; Heating;
参考文献
Richter, Jeremy M.; Whitefield, Brandon W.; Maimone, Thomas J.; Lin, David W.; Castroviejo, M. Pilar; Baran, Phil S.
Journal of the American Chemical Society, 2007 , vol. 129, # 42 p. 12857 - 12869
反应条件
1: 87 percent / sodium borohydride; lithium iodide / tetrahydrofuran / 3 h / Heating
2: 68 percent / p-toluenesulfonic scid / CH2Cl2; tetrahydrofuran / 20 h / 20 °C
View Scheme
参考文献
Oila, Markku J.; Tois, Jan E.; Koskinen, Ari M.P.
Tetrahedron, 2005 , vol. 61, # 45 p. 10748 - 10756
反应条件
trifluoroacetic acid in dichloromethane
5 h; Cooling with ice;
参考文献
Cheng, Xian-Chao; Wang, Run-Ling; Dong, Zhen-Ke; Li, Jing; Li, Yao-Yuan; Li, Rong-Rong
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 19 p. 5738 - 5744
