(S)-(-)-1-(2-萘基)乙醇合成路线 （共 74 条）
反应条件
(R)-7-chloro-2-phenyl-2,3-dihydroimidazo[1,2-a]quinoline; N-ethyl-N,N-diisopropylamine in chloroform T=0°C; 8 h; Product distribution; Further Variations:Reagents;
参考文献
Birman, Vladimir B.; Li, Ximin
Organic Letters, 2006 , vol. 8, # 7 p. 1351 - 1354
反应条件
1: 90 percent / diethyl ether / 2.5 h / 0 - 20 °C 2: IL1 / lipase PS-C / diisopropyl ether / 21.5 h / 35 °C View Scheme
参考文献
Itoh, Toshiyuki; Matsushita, Yuichi; Abe, Yoshikazu; Han, Shi-Hui; Wada, Shohei; Hayase, Shuichi; Kawatsura, Motoi; Takai, Shigeomi; Morimoto, Minoru; Hirose, Yoshihiko
Chemistry - A European Journal, 2006 , vol. 12, # 36 p. 9228 - 9237
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in tetrahydrofuran T=20°C; Inert atmosphereAnhydrous conditions; optical yield given as percent eeenantioselective reaction;
参考文献
Leclercq, Loic; Suisse, Isabelle; Agbossou-Niedercorn, Francine
European Journal of Organic Chemistry, 2010 , # 14 p. 2696 - 2700
反应条件
vinyl acetate; 4 Anstroem molecular sives; lipase LIP in di-isopropyl ether T=30°C; 0.5 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Kato; Katayama; Fujii; Kimoto
Bioscience, biotechnology, and biochemistry, 1995 , vol. 59, # 11 p. 2178 - 2180
反应条件
tertiary amine-based nucleophilic catalyst in 1,1-dimethylpropan-1-ol T=0°C; 15 h;
参考文献
Jeong, Kyu-Sung; Kim, Soong-Hyun; Park, Hyun-Jin; Chang, Kyoung-Jin; Kwan, Soo Kim
Chemistry Letters, 2002 , # 11 p. 1114 - 1115
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in tetrahydrofuran T=20°C; Inert atmosphereAnhydrous conditions; optical yield given as percent ee;
参考文献
Leclercq, Loic; Suisse, Isabelle; Agbossou-Niedercorn, Francine
European Journal of Organic Chemistry, 2010 , # 14 p. 2696 - 2700
反应条件
(R)-(+)-N-methylbenzoguanidine; trimethylacetic anhydride in diethyl ether T=20°C; 12 h; Resolution of racemate; optical yield given as percent ee;
参考文献
Nakata, Kenya; Shiina, Isamu
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 20 p. 7092 - 7096
反应条件
triphenylphosphine; diethylazodicarboxylate in dichloromethane T=-23 - 20°C; Mitsunobu reaction;
参考文献
Chandrasekhar, Sosale; Kulkarni, Guruprasad
Tetrahedron Asymmetry, 2002 , vol. 13, # 6 p. 615 - 619
反应条件
1: diethyl ether / 2 h / 0 °C / Inert atmosphere 2: C28H26N2O; triethylamine / 1,1-dimethylpropan-1-ol / 7 h / 0 °C / Inert atmosphere; Resolution of racemate View Scheme
参考文献
Crittall, Matthew R.; Rzepa, Henry S.; Carbery, David R.
Organic Letters, 2011 , vol. 13, # 5 p. 1250 - 1253
反应条件
1: Candida antarctica B lipase; n-butanol / acetonitrile / 168 h 2: aq. LiOH / methanol / 3 h / Heating View Scheme
参考文献
Swaleh, Sauda M; Hungerhoff, Benno; Sonnenschein, Helmut; Theil, Fritz
Tetrahedron, 2002 , vol. 58, # 20 p. 4085 - 4089
