1-氨基-1-环己基甲酸合成路线 （共 42 条）
反应条件
sodium carbonate in water; ethyl acetate
T=0 - 20°C;
参考文献
SEIKAGAKU CORPORATION
Patent: EP1972615 A1, 2008 ;
Location in patent: Page/Page column 78-79 ;
反应条件
copper(I) bromide dimethylsulfide complex; potassium carbonate in N,N-dimethyl acetamide
T=120°C; 3 h;
参考文献
Shinozuka, Tsuyoshi; Shimada, Kousei; Matsui, Satoshi; Yamane, Takahiro; Ama, Mayumi; Fukuda, Takeshi; Taki, Motohiko; Takeda, Yuko; Otsuka, Eri; Yamato, Michiko; Mochizuki, Shin-ichi; Ohhata, Keiko; Naito, Satoru
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 20 p. 6789 - 6806
反应条件
1: aqueous KOH / 24 h / Ambient temperature
2: 15percent HCl / 1 h / Heating
View Scheme
参考文献
Espada; Pedregal; Alonso; Lopez; Salazar; Martinez; Guillen
Farmaco (Societa chimica italiana : 1989), 1990 , vol. 45, # 11 p. 1237 - 1243
反应条件
sodium hydroxide in water; toluene
T=0 - 10°C; 1.5 h;
参考文献
Satyanarayana; Sumalatha; Sridhar; Venkatraman; Reddy
Synthetic Communications, 2006 , vol. 36, # 14 p. 2079 - 2086
反应条件
1.1: LiAlH4 / tetrahydrofuran / 28 h / 70 - 80 °C
1.2: 68 percent / TEA / methanol / 4 h / 20 °C
2.1: 80 percent / HCl / dioxane / 1 h / 20 °C
View Scheme
参考文献
Mutulis, Felikss; Yahorava, Sviatlana; Mutule, Ilze; Yahorau, Aleh; Liepinsh, Edvards; Kopantshuk, Sergei; Veiksina, Santa; Tars, Kaspars; Belyakov, Sergey; Mishnev, Anatoly; Rinken, Ago; Wikberg, Jarl E. S.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 18 p. 4613 - 4626
反应条件
1: 1-amino-1-cyclo-hexanecarboxylic acid With sodium hydroxide in water
T=80°C; 2 h;
2: furan-2-carbonyl chloride With sodium hydroxide in water
T=0 - 20°C;
3: With hydrogenchloride in water
T=0°C;
参考文献
SEIKAGAKU CORPORATION
Patent: US2009/111983 A1, 2009 ;
Location in patent: Page/Page column 18 ;
US 20090111983 A1
反应条件
1.1: tetrahydrofuran / 3 h / 50 °C / |Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - 0 °C / |Inert atmosphere
2.2: -78 - 20 °C / |Inert atmosphere
View Scheme
参考文献
Schaefer, Gabriel; Bode, Jeffrey W.
Organic Letters, 2014 , vol. 16, # 5 p. 1526 - 1529
反应条件
hydrogenchloride
Heating;
参考文献
GLAXO GROUP LIMITED; UNIVERSITY OF NOTTINGHAM; BRANCH, Clive, Leslie
Patent: WO2008/92878 A1, 2008 ;
Location in patent: Page/Page column 35 ;
WO 2008/092878 A1
反应条件
thionyl chloride
T=25 - 30°C; 1 h; microwave irradiation;
参考文献
Kantharaju; Babu, Vommina V. Suresh
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2006 , vol. 45, # 8 p. 1942 - 1944
反应条件
in methanol
T=0°C; Inert atmosphereReflux;
参考文献
Maegawa, Tomohiro; Otake, Kazuki; Hirosawa, Keiichi; Goto, Akihiro; Fujioka, Hiromichi
Organic Letters, 2012 , vol. 14, # 18 p. 4798 - 4801
