(S)-3-氨基-3-(4-溴苯基)丙酸合成路线 （共 4 条）
反应条件
Lipase Amano PS in phosphate buffer Hydrolysis; resolution of racemate; pH=8.2;
参考文献
Faulconbridge, Susan J.; Holt, Karen E.; Garcia Sevillano, Luis; Lock, Christopher J.; Tiffin, Peter D.; Tremayne, Neil; Winter, Stephen
Tetrahedron Letters, 2000 , vol. 41, # 15 p. 2679 - 2681
反应条件
Pseudomonas cepacia lipase immobilized on diatomite; water in 1,4-dioxane T=45°C; 32.5 h; Enzymatic reaction; optical yield given as percent eestereoselective reaction;
参考文献
Rodriguez-Mata, Maria; Garcia-Urdiales, Eduardo; Gotor-Fernandez, Vicente; Gotor, Vicente
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 2-3 p. 395 - 406
反应条件
1: HCl 2: 46 percent / lipase Amano PS / aq. phosphate buffer / pH 8.2 View Scheme
参考文献
Faulconbridge, Susan J.; Holt, Karen E.; Garcia Sevillano, Luis; Lock, Christopher J.; Tiffin, Peter D.; Tremayne, Neil; Winter, Stephen
Tetrahedron Letters, 2000 , vol. 41, # 15 p. 2679 - 2681
反应条件
1: With borane-THF in tetrahydrofuran
T=0 - 22°C; 30 h;
2: With sodium hydroxide; water in dichloromethane
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2009/47563 A1, 2009 ;
Location in patent: Page/Page column 119 ;
WO 2009/047563 A1
