哌嗪-2-甲酸合成路线

参考文献

Merck and Co., Inc.
Patent: US6316444 B1, 2001 ;
US 6316444 B1

参考文献

Hu, Lain-Yen; Ryder, Todd R.; Nikam, Sham S.; Millerman, Elizabeth; Szoke, Balazs G.; Rafferty, Michael F.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 8 p. 1121 - 1126

2762-32-5哌嗪-2-甲酸

147650-70-2(S)-哌嗪-2-羧酸

参考文献

Beard, Timothy M; Turner, Nicholas J
Chemical communications (Cambridge, England), 2002 , # 3 p. 246 - 247

2762-32-5哌嗪-2-甲酸+

24424-99-5二碳酸二叔丁酯

181955-79-31,4-双(N-Boc)哌嗪-2-甲酸

参考文献

GLAXO GROUP LIMITED
Patent: WO2008/148853 A1, 2008 ;
Location in patent: Page/Page column 157-158 ;
WO 2008/148853 A1

2762-32-5哌嗪-2-甲酸+

73371-96-7

181955-79-31,4-双(N-Boc)哌嗪-2-甲酸

参考文献

Catalano, Alessia; Carocci, Alessia; Corbo, Filomena; Franchini, Carlo; Muraglia, Marilena; Scilimati, Antonio; De Bellis, Michela; De Luca, Annamaria; Camerino, Diana Conte; Sinicropi, Maria Stefania; Tortorella, Vincenzo
European Journal of Medicinal Chemistry, 2008 , vol. 43, # 11 p. 2535 - 2540

186581-53-3重氮甲烷+

2762-32-5哌嗪-2-甲酸

2758-98-7无水硫酸铜

参考文献

Hu, Lain-Yen; Ryder, Todd R.; Nikam, Sham S.; Millerman, Elizabeth; Szoke, Balazs G.; Rafferty, Michael F.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 8 p. 1121 - 1126

2762-32-5哌嗪-2-甲酸+

13139-17-8苯甲氧羰酰琥珀酰亚胺+

58632-95-42-(叔丁氧羰基氧亚氨基)-2-苯乙腈

149057-19-2N-1-Boc-N-4-Cbz-2-哌嗪甲酸

参考文献

BIKAM PHARMACEUTICALS, INC.; GARVEY, David, S.; LAROSA, Gregory, J.; GREENWOOD, Jeremy, Robert; BREWER, Mark, L.; QUACH, Tan; COTE, Jamie, B.; BERMAN, Judd
Patent: WO2010/147653 A1, 2010 ;
Location in patent: Page/Page column 117-118 ;