2,4-二氯-6,7-二甲氧基喹唑啉合成路线 （共 27 条）
反应条件
N,N-dimethyl-aniline; trichlorophosphate
参考文献
DeRuiter; Brubaker; Millen; Riley
Journal of Medicinal Chemistry, 1986 , vol. 29, # 5 p. 627 - 629
反应条件
1: bis(trichloromethyl) carbonate With triethylamine; triphenyl-phosphine oxide in chlorobenzene T=20°C; 0.5 h; Cooling with ice; 2: 2-amino-4,5-dimethoxybenzonitrile in chlorobenzene T=120°C; 8 h;
参考文献
Li, Zhenhua; Wu, Danli; Zhong, Weihui
Heterocycles, 2012 , vol. 85, # 6 p. 1417 - 1426
反应条件
1: 213 g / nitric acid / 1.17 h / cooling 2: hydrogen / Pd/C 3: acid 4: 87 g / phosphorus oxychloride / dimethylformamide / 8 h / Heating View Scheme
参考文献
DeRuiter; Brubaker; Millen; Riley
Journal of Medicinal Chemistry, 1986 , vol. 29, # 5 p. 627 - 629
反应条件
1: hydrogen / Pd/C 2: acid 3: 87 g / phosphorus oxychloride / dimethylformamide / 8 h / Heating View Scheme
参考文献
DeRuiter; Brubaker; Millen; Riley
Journal of Medicinal Chemistry, 1986 , vol. 29, # 5 p. 627 - 629
反应条件
1: HOAc / H2O 2: 85 percent / POCl3, PhNMe2 View Scheme
参考文献
Barbosa, Maria Leticia De Castro; Lima, Lidia Moreira; Tesch, Roberta; Sant'Anna, Carlos Mauricio R.; Totzke, Frank; Kubbutat, Michael H.G.; Schaechtele, Christoph; Laufer, Stefan A.; Barreiro, Eliezer J.
European Journal of Medicinal Chemistry, 2014 , vol. 71, p. 1 - 14
反应条件
1: acid 2: 87 g / phosphorus oxychloride / dimethylformamide / 8 h / Heating View Scheme
参考文献
DeRuiter; Brubaker; Millen; Riley
Journal of Medicinal Chemistry, 1986 , vol. 29, # 5 p. 627 - 629
反应条件
1: Raney nickel; aqueous ammonia; methanol / Hydrogenation.Behandeln der Reaktionsloesung mit Natriumcyanat und Essigsaeure 2: aqueous NaOH 3: N,N-dimethyl-aniline; POCl3 View Scheme
参考文献
Yadav; Naik; Gandhi; Chauhan; Giridhar
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 13 p. 3959 - 3966
反应条件
1: iron; ammonium chloride 2: hydrogenchloride / water View Scheme
参考文献
Yadav; Naik; Gandhi; Chauhan; Giridhar
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 13 p. 3959 - 3966
反应条件
hydrogenchloride in water
参考文献
Yadav; Naik; Gandhi; Chauhan; Giridhar
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 13 p. 3959 - 3966
反应条件
1: aqueous NaOH 2: N,N-dimethyl-aniline; POCl3 View Scheme
参考文献
Curd et al.
Journal of the Chemical Society, 1948 , p. 1759,1765
