2,4-二氯-6,7-二甲氧基喹唑啉合成路线 （共 27 条）
反应条件
potassium hydroxide in toluene 15 h;
参考文献
Volzhina, O. N.; Azimov, V. A.; Medvedev, B. A.; Kazakov, A. A.; Zhikhareva, G. P.; et al.
Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 7 p. 478 - 483
Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 7 p. 802 - 807
反应条件
sodium borohydride in ethanol; dichloromethane; ethyl acetate
参考文献
Isis Pharmaceuticals, Inc.
Patent: US6156758 A1, 2000 ;
反应条件
sodium tetrahydroborate Dehalogenation;
参考文献
Kung, Pei-Pei; Casper, Martin D.; Cook, Kimberley L.; Wilson-Lingardo, Laura; Risen, Lisa M.; Vickers, Timothy A.; Ranken, Ray; Blyn, Lawrence B.; Wyatt, Jacqueline R.; Cook, P. Dan; Ecker, David J.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 22 p. 4705 - 4713
反应条件
potassium hydroxide in tetrahydrofuran; water T=22°C; Inert atmosphereLarge scale;
参考文献
Connolly, Terrence J.; Matchett, Michael; Sarma, Keshab
Organic Process Research and Development, 2005 , vol. 9, # 1 p. 80 - 87
反应条件
ammonia in tetrahydrofuran T=20°C; 44 h;
参考文献
Andrus, Merritt B; Mettath, Sashikumar N; Song, Chun
The Journal of organic chemistry, 2002 , vol. 67, # 23 p. 8284 - 8286
反应条件
in ethanol; acetonitrile 3 h; Heating;
参考文献
Morgalyuk, V. P.; Azimov, V. A.; Bondarenko, V. A.; Denisov, A. V.; Yuzhakov, S. D.; et al.
Pharmaceutical Chemistry Journal, 1991 , vol. 25, # 1 p. 15 - 21
Khimiko-Farmatsevticheskii Zhurnal, 1991 , vol. 25, # 1 p. 28 - 32
反应条件
1: 75 percent / dimethylformamide / 24 h / Ambient temperature 2: 48 percent / ethanol / 14 h / Heating View Scheme
参考文献
Pharmaceutical Chemistry Journal, , vol. 25, # 1 p. 15 - 21
Khimiko-Farmatsevticheskii Zhurnal, , vol. 25, # 1 p. 28 - 32
反应条件
1: 62 percent / hydrazine hydrate / ethanol; acetonitrile / 0.33 h 2: 68 percent / 4 h 3: 45 percent / ethanol / 20 h / Heating View Scheme
参考文献
Pharmaceutical Chemistry Journal, , vol. 25, # 1 p. 15 - 21
Khimiko-Farmatsevticheskii Zhurnal, , vol. 25, # 1 p. 28 - 32
反应条件
1: 75 percent / dimethylformamide / 24 h / Ambient temperature 2: 50 percent / ethanol / 0.5 h / 78 °C View Scheme
参考文献
Morgalyuk, V. P.; Azimov, V. A.; Bondarenko, V. A.; Denisov, A. V.; Yuzhakov, S. D.; et al.
Pharmaceutical Chemistry Journal, 1991 , vol. 25, # 1 p. 15 - 21
Khimiko-Farmatsevticheskii Zhurnal, 1991 , vol. 25, # 1 p. 28 - 32
反应条件
1: 75 percent / dimethylformamide / 24 h / Ambient temperature 2: 51 percent / ethanol / 14 h / Heating View Scheme
参考文献
Morgalyuk, V. P.; Azimov, V. A.; Bondarenko, V. A.; Denisov, A. V.; Yuzhakov, S. D.; et al.
Pharmaceutical Chemistry Journal, 1991 , vol. 25, # 1 p. 15 - 21
Khimiko-Farmatsevticheskii Zhurnal, 1991 , vol. 25, # 1 p. 28 - 32
