bis(1,5-cyclooctadiene)nickel (0); potassium phosphate; cyclohexyl BrettPhos; water in toluene T=100°C; Suzuki-Miyaura coupling; 4 h; Inert atmosphere;

in tetrahydrofuran T=-78 - 20°C; Wittig rearrangement;

1.1: sodium hydride / tetrahydrofuran; dimethyl sulfoxide; mineral oil / 0.33 h / 20 °C / Inert atmosphere 1.2: 0 °C / Inert atmosphere 2.1: potassium phosphate; bis(1,5-cyclooctadiene)nickel (0); cyclohexyl BrettPhos; water / toluene / 4 h / 100 °C / Inert atmosphere View Scheme