4-(4-甲氧基苯甲酰基)苯甲腈合成路线 （共 11 条）
反应条件
bis(acetylacetonate)nickel(II) in tetrahydrofuran T=20°C; Negishi coupling reaction; 0.5 h;
参考文献
Kim, Seung-Hoi; Rieke, Reuben D.
Tetrahedron Letters, 2011 , vol. 52, # 13 p. 1523 - 1526
反应条件
1: para-iodobenzonitrile With isopropylmagnesium chloride in tetrahydrofuran T=-20°C; 2: 4-methoxybenzoyl cyanide With iron (III) acetylacetonate in tetrahydrofuran T=-10°C;
参考文献
Duplais, Christophe; Bures, Filip; Sapountzis, Ioannis; Korn, Tobias J.; Cahiez, Gerard; Knochel, Paul
Angewandte Chemie - International Edition, 2004 , vol. 43, # 22 p. 2968 - 2970
反应条件
3,4,7,8-tetra-methyl-1,10-phenanthroline; oxygen; caesium carbonate; cobalt(II) chloride in toluene; acetonitrile T=80°C; 12 h;
参考文献
Karthikeyan, Jaganathan; Parthasarathy, Kanniyappan; Cheng, Chien-Hong
Chemical Communications, 2011 , vol. 47, # 37 p. 10461 - 10463
反应条件
anhydrous iron chloride; potassium acetate; sodium hydrogencarbonate; iron(II) chloride T=100°C; Suzuki Coupling; P=760.051 Torr; 6 h; Schlenk technique;
参考文献
Zhong, Yanzhen; Han, Wei
Chemical Communications, 2014 , vol. 50, # 29 p. 3874 - 3877
反应条件
1.1: 86 percent / TiCl4 / CH2Cl2 / 2.5 h / 20 °C 2.1: isopropylmagnesium chloride / tetrahydrofuran / -20 °C 2.2: 84 percent / iron(III) acetylacetonate / tetrahydrofuran / -10 °C View Scheme
参考文献
Duplais, Christophe; Bures, Filip; Sapountzis, Ioannis; Korn, Tobias J.; Cahiez, Gerard; Knochel, Paul
Angewandte Chemie - International Edition, 2004 , vol. 43, # 22 p. 2968 - 2970
反应条件
aluminium trichloride 24 h; Ambient temperature;
参考文献
Leigh, William J.; Arnold, Donald R.; Humphreys, Robert W. R.; Wong, Po Cheong
Canadian Journal of Chemistry, 1980 , vol. 58, p. 2537 - 2549
反应条件
(i) DMF, (ii) FeCl3, aq. HCl; Multistep reaction;
参考文献
Diana; Carabateas; Johnson; Williams; Pancic; Collins
Journal of Medicinal Chemistry, 1978 , vol. 21, # 9 p. 889 - 894
反应条件
pyridine hydrochloride T=210°C; 0.333333 h;
参考文献
Wood, Paul M.; Woo, L. W. Lawrence; Labrosse, Jean-Robert; Trusselle, Melanie N.; Abbate, Sergio; Longhi, Giovanna; Castiglioni, Ettore; Lebon, France; Purohit, Atul; Reed, Michael J.; Potter, Barry V. L.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 14 p. 4226 - 4238
反应条件
hydrogenchloride in ethanol
参考文献
Sterling Drug Inc.
Patent: US4153719 A1, 1979 ;
反应条件
hydrogenchloride Heating;
参考文献
Diana; Carabateas; Johnson; Williams; Pancic; Collins
Journal of Medicinal Chemistry, 1978 , vol. 21, # 9 p. 889 - 894
