4-甲氧基-1H-喹啉-2-酮合成路线 （共 21 条）
反应条件
potassium carbonate; dimethyl sulfate in methanol; water; acetone
参考文献
Yu, Kuo-Long; Wang, Xiangdong; Sun, Yaxiong; Cianci, Christopher; Thuring, Jan Willem; Combrink, Keith; Meanwell, Nicholas; Zhang, Yi; Civiello, Rita L.
Patent: US2003/207868 A1, 2003 ;
反应条件
in water T=15°C; Irradiation;
参考文献
Albini, Angelo; Fasani, Elisa; Dacrema, Lucia Maggi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 2738 - 2742
反应条件
hydrogenchloride; acetic acid 4 h; Reflux;
参考文献
Ramasamy; Balasubramaniam; Mohan
E-Journal of Chemistry, 2010 , vol. 7, # 3 p. 1066 - 1070
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Ramasamy; Balasubramaniam; Mohan
Asian Journal of Chemistry, 2012 , vol. 24, # 10 p. 4726 - 4728
反应条件
1: bromoacetic acid N-hydroxysuccinimide ester; triphenylphosphino resin in toluene 16 h; 2: With triethylamine in dichloromethane 16 h; 3: 2-amino-benzoic acid methyl ester in 1,4-dioxane T=180°C; 0.25 h; microwave irradiation; Further stages.;
参考文献
Henkel, Bernd
Synlett, 2008 , # 3 p. 355 - 358
反应条件
potassium carbonate in acetone 2 h; Heating;
参考文献
Chen, Yeh-Long; Hung, Hsien-Ming; Lu, Chih-Ming; Li, Kuang-Chieh; Tzeng, Cherng-Chyi
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 24 p. 6539 - 6546
反应条件
1: 3-Iodo-4-methoxy-2(1H)-quinolinone With isopropylmagnesium chloride in tetrahydrofuran T=-30°C; 0.166667 h; 2: (+/-)-3,3-dimethyloxirane-2-carboxaldehyde in tetrahydrofuran T=-30°C; 0.5 h; Further stages.;
参考文献
Snider, Barry B.; Wu, Xiaoxing
Heterocycles, 2006 , vol. 70, p. 279 - 294
反应条件
1: 3-Iodo-4-methoxy-2(1H)-quinolinone With isopropylmagnesium chloride in tetrahydrofuran T=-30°C; 0.166667 h; 2: (R)-3,3-dimethyloxirane-2-carboxaldehyde in tetrahydrofuran T=-30°C; 0.5 h; Further stages.;
参考文献
Snider, Barry B.; Wu, Xiaoxing
Heterocycles, 2006 , vol. 70, p. 279 - 294
反应条件
triethylamine; p-toluenesulfonyl chloride in chloroform-d1; water 12 h; Ambient temperature;
参考文献
Shichiri; Funakoshi; Saeki; Hamana
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 2 p. 493 - 499
反应条件
1: 70 percent / NaOMe / 24 h / Heating 2: 54 percent / aq. HBr / tetrahydrofuran / 3 h / Heating View Scheme
参考文献
Ramasamy; Balasubramaniam; Mohan
Asian Journal of Chemistry, 2012 , vol. 24, # 10 p. 4726 - 4728
反应条件
in cyclohexane T=15°C; Irradiation;
参考文献
Albini, Angelo; Fasani, Elisa; Dacrema, Lucia Maggi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 2738 - 2742
