4-硝基苄基三苯基溴蓊盐合成路线 （共 32 条）
反应条件
1: sodium carbonate / water / 4 h / 20 °C 2: hydrogenchloride; water; iron / ethanol / 2 h / 0 °C View Scheme
参考文献
Lin, Zhao-Min; Zheng, Chao; Xiao, Jian-Jian; Chen, Run-Feng; Zhao, Ping; Song, Juan; An, Zhong-Fu; Tian, He; Huang, Wei
New Journal of Chemistry, 2012 , vol. 36, # 7 p. 1512 - 1518
反应条件
sodium methylate in tetrahydrofuran T=20°C; Wittig reaction; 72 h;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 58, # 11 p. 1524 - 1528
反应条件
1.1: potassium carbonate / tetrahydrofuran; N,N-dimethyl-formamide / 6 h / |Reflux 2.1: palladium 10 on activated carbon; hydrogen / methanol / 8 h / 20 °C 3.1: dibenzoyl peroxide; tert.-butylnitrite / acetonitrile / 5 h / 20 °C 4.1: sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; toluene / 12 h / |Inert atmosphere; |Reflux 5.1: palladium 10 on activated carbon / methanol / 5 h / 20 °C 6.1: hydrogenchloride / methanol; water / 3 h / 50 °C 6.2: pH 8 - 9 View Scheme
参考文献
Mei, Tie-Wen; Luo, Yu; Feng, Xiang-Jun; Lu, Wei; Yang, Bo
Tetrahedron, 2013 , vol. 69, # 14 p. 2927 - 2932
反应条件
1: Wittig reaction;
2: With iodine in ethyl acetate
Isomerization; Heating;
参考文献
Hooberman; Brezzell; Das; You; Sinsheimer
Mutation Research - Genetic Toxicology, 1994 , vol. 341, # 1 p. 57 - 69
反应条件
potassium tert-butylate in tetrahydrofuran
T=0 - 20°C; 2.16667 h;
参考文献
BAYER CORPORATION
Patent: US2004/2508 A1, 2004 ;
Location in patent: Page/Page column 16-17 ;
US 20040002508 A1
反应条件
1: n-BuLi / cyclohexane; tetrahydrofuran / 1 h / -60 °C
2: cyclohexane; tetrahydrofuran / 24 h / Heating
View Scheme
参考文献
Sandulache, Angela; Silva, Artur M. S.; Pinto, Diana C. G. A.; Almeida, Lucia M. P. M.; Cavaleiro, Jose A. S.
New Journal of Chemistry, 2003 , vol. 27, # 11 p. 1592 - 1598
参考文献
Phukan; Jagtap; Sudalai
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2000 , vol. 39, # 12 p. 950 - 953
反应条件
1: KOtBu
2: Fe, aq. HCl
3: NaNO2, aq. H2SO4
4: H2 / Pd-C
View Scheme
参考文献
Sakai; Santi
Journal of Medicinal Chemistry, 1973 , vol. 16, # 10 p. 1079 - 1084
反应条件
1: (4-nitrobenzyl)(triphenyl)-phosphonium bromide With base
2: p-MeO-cinnamaldehyde Wittig reaction;
参考文献
Vangala, Venu R.; Bhogala, Balakrishna R.; Dey, Archan; Desiraju, Gautam R.; Broder, Charlotte K.; Smith, Philip S.; Mondal, Raju; Howard, Judith A. K.; Wilson, Chick C.
Journal of the American Chemical Society, 2003 , vol. 125, # 47 p. 14495 - 14509
反应条件
sodium hydride in diethyl ether
1.)two days, ultrasonic bath, 2.) 10-15 min.; Yield given;
参考文献
Rafizadeh, Karim; Yates, Keith
Journal of Organic Chemistry, 1984 , vol. 49, # 9 p. 1500 - 1506
