(R)-(+)-3-羟基-3-苯丙酸合成路线 （共 59 条）
反应条件
1: With sodium hydroxide in tetrahydrofuran; water 2 h; RefluxInert atmosphere; 2: With hydrogenchloride in tetrahydrofuran; water pH=3; Inert atmosphere;
参考文献
Khatik, Gopal L.; Sharma, Ratnesh; Kumar, Varun; Chouhan, Mangilal; Nair, Vipin A.
Tetrahedron Letters, 2013 , vol. 54, # 45 p. 5991 - 5993
反应条件
Synechocystis sp. PCC 6803 nitrilase in phosphate buffer T=30°C; pH=7.2; 24 h;
参考文献
Zhu, Dunming; Ankati, Haribabu; Mukherjee, Chandrani; Yang, Van; Biehl, Edward R.; Hua, Ling
Organic Letters, 2007 , vol. 9, # 13 p. 2560 - 2563
反应条件
1: With D-glucose; carbonyl reductase from Candida magnoliae; D-glucose dehydrogenase; NADPH in dimethyl sulfoxide T=20°C; pH=7.0; 60 h; potassium phosphate bufferEnzymatic reaction; 2: With nitrilase from cyanobacterium Synechocystis sp. strain PCC 6803 in dimethyl sulfoxide T=30°C; pH=7.2; 24 h; potassium phosphate bufferEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Ankati, Haribabu; Zhu, Dunming; Yang, Yan; Biehl, Edward R.; Hua, Ling
Journal of Organic Chemistry, 2009 , vol. 74, # 4 p. 1658 - 1662
反应条件
lithium hydroxide; dihydrogen peroxide in tetrahydrofuran; water T=0°C; 3 h;
参考文献
Bond, Silas; Perlmutter, Patrick
Journal of Organic Chemistry, 1997 , vol. 62, # 18 p. 6397 - 6400
反应条件
1: With water; triethylamine in dichloromethane T=0°C; Hydrolysis; 0.5 h; 2: With aluminium amalgam in dichloromethane T=0°C; Dehalogenation; 0.166667 h; Further stages.;
参考文献
Wang, Ying-Chuan; Yan, Tu-Hsin
Journal of Organic Chemistry, 2000 , vol. 65, # 20 p. 6752 - 6755
反应条件
lithium hydroxide in tetrahydrofuran; water T=0°C; 1 h;
参考文献
Orsini, Fulvia; Sello, Guido; Manzo, Angelo Maria; Lucci, Elvira Maria
Tetrahedron Asymmetry, 2005 , vol. 16, # 11 p. 1913 - 1918
反应条件
water; sodium hydroxide in tetrahydrofuran 2 h; Reflux;
参考文献
Khatik, Gopal L.; Kumar, Varun; Nair, Vipin A.
Organic Letters, 2012 , vol. 14, # 10 p. 2442 - 2445
反应条件
potassium hydroxide in methanol T=0°C; 0.75 h; Title compound not separated from byproducts;
参考文献
Evans, D. A.; Bartroli, J.; Shih, T. L.
Journal of the American Chemical Society, 1981 , vol. 103, # 8 p. 2127 - 2129
反应条件
sodium hydroxide in methanol Ambient temperature;
参考文献
Boaz, Neil W.
Journal of Organic Chemistry, 1992 , vol. 57, # 15 p. 4289 - 4292
反应条件
lithium hydroxide; dihydrogen peroxide in tetrahydrofuran T=0°C; 3 h;
参考文献
Yan, Tu-Hsin; Hung, An-Wei; Lee, Hui-Chun; Chang, Chii-Shin; Liu, Wen-Hung
Journal of Organic Chemistry, 1995 , vol. 60, # 11 p. 3301 - 3306
