(R)-(+)-3-羟基-3-苯丙酸合成路线 （共 59 条）
反应条件
2: hydrolysis View Scheme
参考文献
Ishihara, Kazuaki; Maruyama, Tohru; Mouri, Makoto; Gao, Qingzhi; Furuta,Kyoji; Yamamoto, Hisashi
Bulletin of the Chemical Society of Japan, 1993 , vol. 66, # 11 p. 3483 - 3491
反应条件
potassium hydroxide in methanol; water 15 h; Heating;
参考文献
Braun, Manfred; Devant, Ralf
Angewandte Chemie, 1983 , vol. 95, # 10 p. 802 - 803
反应条件
lithium hydroxide; dihydrogen peroxide in tetrahydrofuran; water T=0°C;
参考文献
Luetzen, Arne; Koell, Peter
Tetrahedron Asymmetry, 1997 , vol. 8, # 8 p. 1193 - 1206
反应条件
1: (-)-(R)-3-acyl-[2.2]paracyclophano[4,5-d]-1,3-oxazol-2(3H)-one With di-n-butylboryl trifluoromethanesulfonate; triethylamine in dichloromethane T=0°C; 1 h; 2: benzaldehyde in dichloromethane T=-78 - 0°C; 3.5 h; 3: With phosphate buffer; dihydrogen peroxide in methanol; dichloromethane; water T=0°C; pH=7.0; 1 h; Further stages. Title compound not separated from byproducts.;
参考文献
Fringuelli, Francesco; Piermatti, Oriana; Pizzo, Ferdinando; Scappini, Anna Maria
Gazzetta Chimica Italiana, 1995 , vol. 125, # 4 p. 195 - 200
反应条件
Pseudomonas cepacia lipase immobilized on gold nanoparticles in aq. phosphate buffer T=23°C; 8 h; Resolution of racemateEnzymatic reaction; Catalytic behavior; Reagent/catalystTime;
参考文献
Jedrzejewska, Hanna; Ostaszewski, Ryszard
Journal of Molecular Catalysis B: Enzymatic, 2013 , vol. 90, p. 12 - 16
反应条件
1: With sodium hydroxide; pig liver esterase in phosphate buffer T=20°C; resolution of racemate; pH=8.0; 0.5 h; ultrasound; 2: With hydrogenchloride in water pH=1;
参考文献
Ribeiro, Carlos Magno R.; Passaroto, Elisa N.; Brenelli, Eugenia C.S.
Tetrahedron Letters, 2001 , vol. 42, # 37 p. 6477 - 6479
反应条件
1: With hydrogen fluoride in acetonitrile T=20°C; 2: With sodium periodate in methanol; water T=20°C; optical yield given as percent ee;
参考文献
Lorente, Adriana; Pellicena, Miquel; Romea, Pedro; Urpi, Felix
Tetrahedron Letters, 2010 , vol. 51, # 6 p. 942 - 945
反应条件
sodium hydroxide 16 h; Ambient temperature;
参考文献
Duthaler, Rudolf O.; Herold, Peter; Lottenbach, Willy; Oertle, Konrad; Riediker, Martin
Angewandte Chemie, 1989 , vol. 101, # 4 p. 490 - 491
反应条件
1: H2 / palladium on charcoal / methanol / 5 h / Ambient temperature 2: 0.08 g / HBF4*Et2O / CH2Cl2 / 3 h / Ambient temperature 3: peracetic acid, Et3N / diethyl ether; acetic acid / 16 h / Ambient temperature View Scheme
参考文献
Fleming, Ian; Kindon, Nicolas D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 4 p. 303 - 316
反应条件
1.1: tetrahydrofuran / 0 °C 1.2: tetrahydrofuran / 55 h / 20 °C 2.1: H2O2; aq. NaOH / tetrahydrofuran View Scheme
参考文献
Ramachandran, P. Veeraraghavan; Pitre, Sangeeta; Brown, Herbert C.
Journal of Organic Chemistry, 2002 , vol. 67, # 15 p. 5315 - 5319
