(R)-(+)-3-羟基-3-苯丙酸合成路线 （共 59 条）
反应条件
1: NEt3 / CH2Cl2 2: lipase PS-30 from Pseudomonas sp., phosphate buffer pH 7 View Scheme
参考文献
Boaz, Neil W.
Journal of Organic Chemistry, 1992 , vol. 57, # 15 p. 4289 - 4292
反应条件
1: lipase PS-30 from Pseudomonas sp., phosphate buffer pH 7 2: 80 percent / 10percent aq. NaOH / methanol / Ambient temperature View Scheme
参考文献
Boaz, Neil W.
Journal of Organic Chemistry, 1992 , vol. 57, # 15 p. 4289 - 4292
反应条件
lithium hydroxide; dihydrogen peroxide T=0°C;
参考文献
Oppolzer, Wolfgang; Starkemann, Christian
Tetrahedron Letters, 1992 , vol. 33, # 18 p. 2439 - 2442
反应条件
1: 39.5 percent / KCN; DMAP / methanol / 23 h / 20 °C 2: 57.4 percent / aq. NaOH; H2O2 / 6.5 h / 20 °C View Scheme
参考文献
Meisterhans, Christian; Linden, Anthony; Hesse, Manfred
Helvetica Chimica Acta, 2003 , vol. 86, # 3 p. 644 - 656
反应条件
sodium hydroxide; iodine; potassium iodide in 1,4-dioxane; water 0.5 h;
参考文献
Cambie, Richard C.; Coddington, Jan M.; Milbank, Jared B. J.; Pausler, Maria G.; Rustenhoven, Job J.; et al.
Australian Journal of Chemistry, 1993 , vol. 46, # 5 p. 583 - 591
反应条件
1: O3 / CH2Cl2 / -78 °C 2: NaOH, I2, KI / H2O; dioxane / 0.5 h View Scheme
参考文献
Cambie, Richard C.; Coddington, Jan M.; Milbank, Jared B. J.; Pausler, Maria G.; Rustenhoven, Job J.; et al.
Australian Journal of Chemistry, 1993 , vol. 46, # 5 p. 583 - 591
反应条件
potassium hydroxide in methanol; water Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Braun, Manfred; Devant, Ralf
Tetrahedron Letters, 1984 , vol. 25, # 44 p. 5031 - 5034
反应条件
sodium hydroxide; Pseudomonas candida lipase in phosphate buffer T=20°C; resolution of racemate; pH=7.0; 24 h; ultrasound; Product distribution; Further Variations:pH-valuesReagentsmagnetic stirring;
参考文献
Ribeiro, Carlos Magno R.; Passaroto, Elisa N.; Brenelli, Eugenia C.S.
Tetrahedron Letters, 2001 , vol. 42, # 37 p. 6477 - 6479
反应条件
1: pyridinium dichromate / dimethylformamide / 22 h / Ambient temperature 2: 0.08 g / HBF4*Et2O / CH2Cl2 / 3 h / Ambient temperature 3: peracetic acid, Et3N / diethyl ether; acetic acid / 16 h / Ambient temperature View Scheme
参考文献
Fleming, Ian; Kindon, Nicolas D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 4 p. 303 - 316
反应条件
1: pyridinium dichromate, 3A molecular sieves / dimethylformamide / 24 h / Ambient temperature 2: 0.08 g / HBF4*Et2O / CH2Cl2 / 3 h / Ambient temperature 3: peracetic acid, Et3N / diethyl ether; acetic acid / 16 h / Ambient temperature View Scheme
参考文献
Fleming, Ian; Kindon, Nicolas D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 4 p. 303 - 316
