Z-ALA-PHE-OH合成路线 （共 18 条）
反应条件
in N,N-dimethyl-formamide
参考文献
Gibson, Frank S.; Park, Myung Sook; Rapoport, Henry
Journal of Organic Chemistry, 1994 , vol. 59, # 24 p. 7503 - 7507
反应条件
pyridine; sodium chloride; triethylamine in N,N-dimethyl-formamide
参考文献
Ogura; Haruo
Patent: US4341707 A1, 1982 ;
反应条件
N'''-tert-butyl-N,N,N',N',N'',N''-hexamethylphosphorimidic triamide in acetonitrile
T=20°C; 0.0833333 h;
参考文献
Palomo, Claudio; Palomo, Antonio L; Palomo, Francisco; Mielgo, Antonia
Organic letters, 2002 , vol. 4, # 23 p. 4005 - 4008
反应条件
triethylamine in water; acetonitrile
T=20°C;
参考文献
Katritzky, Alan R.; Suzuki, Kazuyuki; Singh, Sandeep K.
Synthesis, 2004 , # 16 p. 2645 - 2652
反应条件
lithium hydroxide in tetrahydrofuran
T=0°C; 0.5 h;
参考文献
Gibson, Frank S.; Park, Myung Sook; Rapoport, Henry
Journal of Organic Chemistry, 1994 , vol. 59, # 24 p. 7503 - 7507
反应条件
1.1: SOCl2 / tetrahydrofuran / 0.33 h / 25 °C
1.2: 95 percent / tetrahydrofuran / 1 h / 25 °C
2.1: 90 percent / Et3N / acetonitrile; H2O / 20 °C
View Scheme
参考文献
Katritzky, Alan R.; Suzuki, Kazuyuki; Singh, Sandeep K.
Synthesis, 2004 , # 16 p. 2645 - 2652
反应条件
cross-linked enzyme aggregate of Alcalase; water
T=37°C; 16 h; Enzymatic reaction;
参考文献
Nuijens, Timo; Cusan, Claudia; Schepers, Annette C.H.M.; Kruijtzer, John A.W.; Rijkers, Dirk T.S.; Liskamp, Rob M.J.; Quaedflieg, Peter J.L.M.
Journal of Molecular Catalysis B: Enzymatic, 2011 , vol. 71, # 1-2 p. 79 - 84
反应条件
in N,N-dimethyl-formamide
T=20°C; Condensation; 2 h;
参考文献
Raydnov, M. G.; Klimenko, L. V.; Mitin, Yu. V.
Russian Journal of Bioorganic Chemistry, 1999 , vol. 25, # 5 p. 283 - 287
Bioorganicheskaya Khimiya, 1999 , vol. 25, # 5 p. 323 - 328
反应条件
chloroform; triethylamine; toluene
anschliessendes Behandeln mit L-Phenylalanin-aethylester und Behandeln des Reaktionsprodukts mit wss. NaOH;
参考文献
Fu et al.
Journal of the American Chemical Society, 1954 , vol. 76, p. 6054,6057
反应条件
1: 93 percent / bis<<4-(2,2-dimethyl-1,3-dioxolyl)methyl>carbodiimide, Et3N / dimethylformamide / 24 h / Ambient temperature
2: 97 percent / aq. LiOH / tetrahydrofuran / 0.5 h / 0 °C
View Scheme
参考文献
Gibson, Frank S.; Park, Myung Sook; Rapoport, Henry
Journal of Organic Chemistry, 1994 , vol. 59, # 24 p. 7503 - 7507
