3-(4-氯丁酰基)-1H-吲哚-5-甲腈合成路线 （共 6 条）
反应条件
AlCl3, aluminium chloride in dichloromethane 0.5 h; Reflux;
参考文献
ERREGIERRE S.p.A.; Ferrari, Massimo; De Zani, Daniele; Bonaldi, Matteo
Patent: EP2647625 A1, 2013 ;
Location in patent: Paragraph 0055; 0056; 0057 ;
反应条件
isobutylaluminium dichloride in dichloromethane Friedel-Crafts Acylation;
参考文献
Hu, Bin; Song, Qiao; Xu, Yungen
Organic Process Research and Development, 2012 , vol. 16, # 9 p. 1552 - 1557
反应条件
1: 26 percent / sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran; toluene / 2 h 2: K2CO3; Et3N / acetonitrile / 12 h / Heating 3: KOH / methanol / 3 h / Heating 4: 72 percent / 1-methyl-2-chloropyridinium iodide; Et2NiPr; NH3(g) / 1-methyl-pyrrolidin-2-one View Scheme
参考文献
Hu, Bin; Song, Qiao; Xu, Yungen
Organic Process Research and Development, 2012 , vol. 16, # 9 p. 1552 - 1557
反应条件
chloro-trimethyl-silane; sodium cyanoborohydride in acetonitrile T=0 - 30°C;
参考文献
SYMED LABS LIMITED; MOHAN RAO, Dodda; JITHENDER, Aadepu
Patent: WO2014/6637 A2, 2014 ;
Location in patent: Page/Page column 41; 42 ;
反应条件
1: 26 percent / sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran; toluene / 2 h 2: K2CO3; Et3N / acetonitrile / 12 h / Heating View Scheme
参考文献
Hu, Bin; Song, Qiao; Xu, Yungen
Organic Process Research and Development, 2012 , vol. 16, # 9 p. 1552 - 1557
反应条件
1: 26 percent / sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran; toluene / 2 h 2: K2CO3; Et3N / acetonitrile / 12 h / Heating 3: KOH / methanol / 3 h / Heating View Scheme
参考文献
Heinrich, Timo; Boettcher, Henning; Gericke, Rolf; Bartoszyk, Gerd D.; Anzali, Soheila; Seyfried, Christoph A.; Greiner, Hartmut E.; Van Amsterdam, Christoph
Journal of Medicinal Chemistry, 2004 , vol. 47, # 19 p. 4684 - 4692
