1-叔丁氧羰基-3-亚甲基哌啶合成路线 （共 8 条）
反应条件
potassium tert-butylate in toluene T=30°C;
参考文献
US2009/275585 A1, ;
Page/Page column 13; 17 ;
US 20090275585 A1
反应条件
1: triphenyl-methyl-phosphonium iodide With potassium tert-butylate in tetrahydrofuran T=-78 - 20°C; 1.33333 h; 2: (tert-Butoxycarbonyl)piperidin-3-one T=0 - 20°C; 0.166667 h;
参考文献
WO2006/85212 A2, ;
Page/Page column 44 ;
反应条件
1: N-(3-phenylselenopropyl)-2-methyleneaziridine With 2,2'-azo-bisisobutyronitrile; tri-n-butyl-tin hydride in benzene 6 h; Heating; 2: di-tert-butyl dicarbonate With triethylamine in benzene T=20°C; Further stages.;
参考文献
Prevost, Natacha; Shipman, Michael
Organic Letters, 2001 , vol. 3, # 15 p. 2383 - 2385
反应条件
1: 70 percent / tri-n-butylphosphine / tetrahydrofuran / 4 h / 0 °C 2: 88 percent / NaNH2; NH3 / 0.42 h 3: Bu3SnH; AIBN / benzene / 6 h / Heating 4: 45 mg / triethylamine / benzene / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 58, # 35 p. 7165 - 7175
反应条件
1: 88 percent / NaNH2; NH3 / 0.42 h 2: Bu3SnH; AIBN / benzene / 6 h / Heating 3: 45 mg / triethylamine / benzene / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 58, # 35 p. 7165 - 7175
反应条件
triethylamine in benzene T=20°C;
参考文献
Prevost, Natacha; Shipman, Michael
Tetrahedron, 2002 , vol. 58, # 35 p. 7165 - 7175
反应条件
1: Methyltriphenylphosphonium bromide With potassium tert-butylate in tetrahydrofuran 0.75 h; Reflux; 2: (tert-Butoxycarbonyl)piperidin-3-one in tetrahydrofuran T=20°C; Wittig reaction; 1 h;
参考文献
European Journal of Medicinal Chemistry, , vol. 46, # 12 p. 5790 - 5799
反应条件
1: Bu3SnH; AIBN / benzene / 6 h / Heating 2: 45 mg / triethylamine / benzene / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 58, # 35 p. 7165 - 7175
