7-(3-氯丙基)-1,3-二甲基嘌呤-2,6-二酮合成路线 （共 4 条）
反应条件
1: 1,3-dimethylxanthine With sodium hydride in N,N-dimethyl-formamide
T=20°C; 0.166667 h;
2: 1-bromo-3-chloro-propane in N,N-dimethyl-formamide
T=20°C; 24 h; Further stages.;
参考文献
Kim, Soon-Ai; Marshall, Melissa A.; Melman, Neli; Kim, Hak Sung; Mueller, Christa E.; Linden, Joel; Jacobson, Kenneth A.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 11 p. 2131 - 2138
反应条件
sodium hydroxide; Aliquatreg; 336
2 h; Heating;
参考文献
Kalcheva, Veneta B.; Apostolova, Tatiana M.; Anakieva, Violeta Z.
Journal fuer Praktische Chemie (Leipzig), 1985 , vol. 327, # 1 p. 165 - 168
反应条件
sodium hydroxide; Aliquatreg; 336
5 h; Heating;
参考文献
Kalcheva, Veneta B.; Apostolova, Tatiana M.; Anakieva, Violeta Z.
Journal fuer Praktische Chemie (Leipzig), 1985 , vol. 327, # 1 p. 165 - 168
反应条件
sodium iodide in N-methyl-acetamide
参考文献
Chinoin Gyogyszer-es Vegyeszeti Termekek Gyara R.T.
Patent: US4565817 A1, 1986 ;
