1: With sodium methylate in ethanol
T=70 - 75°C; 3 h;
2: With sodium hydroxide in water
pH=11;
3: With hydrogenchloride in water
pH=5.5; Product distribution / selectivity;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2007/71742 A1, 2007 ;
Location in patent: Page/Page column 19 ;
1: With sodium ethanolate in ethanol
T=65 - 75°C; 3 h;
2: With sodium hydroxide in water
pH=11;
3: With hydrogenchloride in water
pH=2 - 4; Product distribution / selectivity;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2007/71742 A1, 2007 ;
Location in patent: Page/Page column 20 ;