3,5-二乙氧基-2-氟苯甲醛合成路线 （共 4 条）
反应条件
potassium fluoride in N,N-dimethyl-formamide T=20°C; 2 h;
参考文献
Zbinden, Katrin Groebke; Banner, David W.; Hilpert, Kurt; Himber, Jacques; Lave, Thierry; Riederer, Markus A.; Stahl, Martin; Tschopp, Thomas B.; Obst-Sander, Ulrike
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 15 p. 5357 - 5369
反应条件
1.1: 91 percent / imidazole / dimethylformamide / 1 h / 0 °C 2.1: sec-BuLi / tetrahydrofuran; hexane / 0.5 h / -65 °C 2.2: trimethyl borate / tetrahydrofuran; hexane / 1 h / -65 °C 2.3: 73 percent / aq. H2O2; acetic acid / 0.5 h / 0 °C 3.1: 99 percent / imidazole / dimethylformamide / 1 h / 0 °C 4.1: sec-BuLi / tetrahydrofuran; hexane / 1 h / -70 °C 4.2: 92 percent / tetrahydrofuran; hexane / 1.5 h / 20 °C 5.1: 55 percent / KF / dimethylformamide / 2 h / 20 °C View Scheme
参考文献
Zbinden, Katrin Groebke; Banner, David W.; Hilpert, Kurt; Himber, Jacques; Lave, Thierry; Riederer, Markus A.; Stahl, Martin; Tschopp, Thomas B.; Obst-Sander, Ulrike
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 15 p. 5357 - 5369
反应条件
1.1: sec-BuLi / tetrahydrofuran; hexane / 0.5 h / -65 °C 1.2: trimethyl borate / tetrahydrofuran; hexane / 1 h / -65 °C 1.3: 73 percent / aq. H2O2; acetic acid / 0.5 h / 0 °C 2.1: 99 percent / imidazole / dimethylformamide / 1 h / 0 °C 3.1: sec-BuLi / tetrahydrofuran; hexane / 1 h / -70 °C 3.2: 92 percent / tetrahydrofuran; hexane / 1.5 h / 20 °C 4.1: 55 percent / KF / dimethylformamide / 2 h / 20 °C View Scheme
参考文献
Zbinden, Katrin Groebke; Banner, David W.; Hilpert, Kurt; Himber, Jacques; Lave, Thierry; Riederer, Markus A.; Stahl, Martin; Tschopp, Thomas B.; Obst-Sander, Ulrike
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 15 p. 5357 - 5369
反应条件
1.1: sec-BuLi / tetrahydrofuran; hexane / 1 h / -70 °C 1.2: 92 percent / tetrahydrofuran; hexane / 1.5 h / 20 °C 2.1: 55 percent / KF / dimethylformamide / 2 h / 20 °C View Scheme
参考文献
Zbinden, Katrin Groebke; Banner, David W.; Hilpert, Kurt; Himber, Jacques; Lave, Thierry; Riederer, Markus A.; Stahl, Martin; Tschopp, Thomas B.; Obst-Sander, Ulrike
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 15 p. 5357 - 5369
