2-乙酸基-4-苄氧基吲哚合成路线 （共 11 条）
反应条件
potassium carbonate in dichloromethane; dimethyl sulfoxide
参考文献
Novuspharma S.p.A.
Patent: EP1200439 B1, 2003 ;
反应条件
1: With ethanol; sodium ethanolate T=-10°C; 10 h; Heating; 2: in toluene T=125°C; 3 h;
参考文献
Sheng, Chunquan; Xu, Hui; Wang, Wenya; Cao, Yongbing; Dong, Guoqiang; Wang, Shengzheng; Che, Xiaoying; Ji, Haitao; Miao, Zhenyuan; Yao, Jianzhong; Zhang, Wannian
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 9 p. 3531 - 3540
反应条件
1: sodium / ethanol / 6.5 h / -10 - -5 °C 2: 66 percent / chlorobenzene / 0.33 h / Heating View Scheme
参考文献
Henn, Lothar; Hickey, Deirde M. B.; Moody, Christopher J.; Rees, Charles W.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 2189 - 2197
反应条件
in toluene 3 h; Heating; Yield given;
参考文献
Gray, Nancy M.; Dappen, Michael S.; Cheng, Brian K.; Cordi, Alexis A.; Biesterfeldt, John P.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 4 p. 1283 - 1292
反应条件
in toluene 2.75 h; Heating;
参考文献
Henn, Lothar; Hickey, Deirde M. B.; Moody, Christopher J.; Rees, Charles W.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 2189 - 2197
反应条件
hydrogen; palladium 10 on activated carbon in methanol; dichloromethane 24 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GmbH
Patent: WO2005/77932 A2, 2005 ;
Location in patent: Page/Page column 64-65 ;
WO 2005/077932 A2
反应条件
magnesium T=20°C; Inert atmosphere;
参考文献
SPINIFEX PHARMACEUTICALS PTY LTD; MCCARTHY, Thomas David; NAYLOR, Alan
Patent: WO2013/102242 A1, 2013 ;
Location in patent: Page/Page column 77 ;
反应条件
1: 79 percent / 50percent aq. NaOH / ethanol / 0.25 h / Heating 2: 58 percent / H2 / 10percent Pd/C / ethyl acetate; ethanol / 3 h / 2585.7 Torr / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 4 p. 1283 - 1292
反应条件
iodine cloride; acetic acid
T=20°C;
参考文献
Al-Said, Naim H.; Shawakfeh, Khaled Q.; Abdullah, Wasim N.
Molecules, 2005 , vol. 10, # 12 p. 1446 - 1457
反应条件
sodium hydroxide in ethanol
0.25 h; Heating;
参考文献
Gray, Nancy M.; Dappen, Michael S.; Cheng, Brian K.; Cordi, Alexis A.; Biesterfeldt, John P.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 4 p. 1283 - 1292
