3,4-(亚甲二氧基)苦杏仁酸合成路线 （共 17 条）
反应条件
hydrogenchloride; potassium hydroxide; lithium chloride in 1,4-dioxane; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; water
参考文献
Banyu Pharmaceutical Co., Ltd.
Patent: US5403835 A1, 1995 ;
反应条件
acetic acid; sodium nitrite T=65°C; 4 h;
参考文献
Boehme, E. H. W.; Bambury, R. E.; Baumann, R. J.; Erickson, R. C.; Harrison, B. L.; et al.
Journal of Medicinal Chemistry, 1980 , vol. 23, # 4 p. 405 - 412
反应条件
potassium hydroxide; lithium chloride in 1,4-dioxane; water 1.) from 5 to 10 deg C, 30 h, 2.) 25 deg C, 65 h;
参考文献
Raucher; Jones; Stenkamp
Journal of Organic Chemistry, 1985 , vol. 50, # 23 p. 4523 - 4526
反应条件
ammonium hydroxide; sulfuric acid; acetic acid
参考文献
Ube Industries, Ltd.
Patent: US6603024 B1, 2003 ;
反应条件
ammonium hydroxide; sulfuric acid
参考文献
Ube Industries, Ltd.
Patent: US6603024 B1, 2003 ;
反应条件
in trifluoroacetic acid
参考文献
Haarmann and Reimer GmbH
Patent: US4190583 A1, 1980 ;
反应条件
ammonium hydroxide; sulfuric acid
参考文献
Ube Industries, Ltd.
Patent: US6603024 B1, 2003 ;
反应条件
sulfuric acid in water T=0 - 5°C; 20 h;
参考文献
Bjorsvik, Hans-Rene; Liguori, Lucia; Minisci, Francesco
Organic Process Research and Development, 2000 , vol. 4, # 6 p. 534 - 543
反应条件
1: 74 percent / ethanol; H2O / 2 h / Heating 2: 35 percent / Ba(OH)2*8H2O / H2O / 18 h / Heating 3: 65 percent / aq. NaNO2, AcOH / 4 h / 65 °C View Scheme
参考文献
Boehme, E. H. W.; Bambury, R. E.; Baumann, R. J.; Erickson, R. C.; Harrison, B. L.; et al.
Journal of Medicinal Chemistry, 1980 , vol. 23, # 4 p. 405 - 412
反应条件
1: 35 percent / Ba(OH)2*8H2O / H2O / 18 h / Heating 2: 65 percent / aq. NaNO2, AcOH / 4 h / 65 °C View Scheme
参考文献
Boehme, E. H. W.; Bambury, R. E.; Baumann, R. J.; Erickson, R. C.; Harrison, B. L.; et al.
Journal of Medicinal Chemistry, 1980 , vol. 23, # 4 p. 405 - 412
