oxygen; sodium hydride in tetrahydrofuran T=0 - 20°C; 6 h;

1: 2-bromo-pyridine With n-butyllithium; n-butyl-magnesium chloride; (S)-(minus;)-1,1'-bi-2-naphthol in hexane; water; toluene T=-5 - 20°C; 1 h; Inert atmosphere; 2: 4-methoxy-benzaldehyde in tetrahydrofuran; hexane; toluene T=20 - 60°C; 1 h; Inert atmosphere; 3: With hydrogenchloride in tetrahydrofuran; hexane; water; toluene pH=3 - 4; Inert atmosphere;

1: 1-bromo-4-methoxy-benzene With magnesium in tetrahydrofuran T=20°C; Reflux; 2: pyridine-2-carbaldehyde in tetrahydrofuran T=0°C; Reflux; 3: With water; ammonium chloride in tetrahydrofuran

in tetrahydrofuran T=20°C; 10 h;

1: pyridine-2-carbaldehyde With aluminum tribromide in dichloromethane T=0°C; Friedel-Crafts Alkylation; 0.5 h; Inert atmosphere; 2: methoxybenzene in dichloromethane T=20°C; Friedel-Crafts Alkylation; 24 h; Inert atmosphere;

pyridinium trifluoroacetate in ethanol 24 h; Heating;

1: 2-bromo-pyridine With nBu4ZnLi2*TMEDA in toluene T=20°C; 1 h; Inert atmosphere; 2: 4-methoxy-benzaldehyde in tetrahydrofuran; toluene T=20°C; 18 h; Inert atmosphere;

diethyl ether

pyridine; magnesium

1: 2-bromo-pyridine; n-butyl-magnesium chloride in toluene T=-5°C; 1 h; Inert atmosphere; 2: 4-methoxy-benzaldehyde in tetrahydrofuran; hexane; toluene T=-5°C; 1 h; Inert atmosphere; 3: With hydrogenchloride in water; toluene pH=3 - 4; Inert atmosphere;