1,4-二甲基-1H-吲哚合成路线 （共 11 条）
反应条件
1: With potassium tert-butylate in DMF (N,N-dimethyl-formamide) T=20°C; 0.583333 h; 2: With oxalic acid dimethyl ester in DMF (N,N-dimethyl-formamide) T=120°C; 5.5 h;
参考文献
Tsuchiya, Naoki; Matsumoto, Yoshiyuki; Saitou, Hiroshi; Mizuno, Tsuyoshi
Patent: US2004/10004 A1, 2004 ;
Location in patent: Page 26-27 ;
反应条件
sodium hydride in N,N-dimethyl-formamide T=0 - 20°C;
参考文献
Lo, Ho Yin; Nemoto, Peter A.; Kim, Jin Mi; Hao, Ming-Hong; Qian, Kevin C.; Farrow, Neil A.; Albaugh, Daniel R.; Fowler, Danielle M.; Schneiderman, Richard D.; Michael August; Martin, Leslie; Hill-Drzewi, Melissa; Pullen, Steven S.; Takahashi, Hidenori; De Lombaert, Stephane
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 15 p. 4533 - 4539
反应条件
Ni(PCy3)2Cl2; 1,1,3,3-tetramethyldisiloxane; K3PO4 in toluene T=125°C; 15 h; Inert atmosphere;
参考文献
Mesganaw, Tehetena; Fine Nathel, Noah F.; Garg, Neil K.
Organic Letters, 2012 , vol. 14, # 11 p. 2918 - 2921
反应条件
2: 79 percent / quinone, LiCl / PdCl2(MeCN)2 / tetrahydrofuran / 10 h / Heating View Scheme
参考文献
Yamaguchi, Masahiko; Arisawa, Mieko; Hirama, Masahiro
Chemical Communications, 1998 , # 13 p. 1399 - 1400
反应条件
1.1: N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium / tetrahydrofuran / 1.25 h / -78 °C / Inert atmosphere 1.2: 2.02 h / -78 - 23 °C / Inert atmosphere 2.1: Ni(PCy3)2Cl2; K3PO4; 1,1,3,3-tetramethyldisiloxane / toluene / 15 h / 125 °C / Inert atmosphere View Scheme
参考文献
Mesganaw, Tehetena; Fine Nathel, Noah F.; Garg, Neil K.
Organic Letters, 2012 , vol. 14, # 11 p. 2918 - 2921
反应条件
in N,N-dimethyl-formamide Ambient temperature;
参考文献
Yurovskaya; Afanasyev; Maximova; Bundel
Tetrahedron, 1993 , vol. 49, # 22 p. 4945 - 4954
反应条件
methylamine 1.) 30 min cooled, 2.) R.T., 2 d.;
参考文献
Yurovskaya, M. A.; Chertkov, V. A.; Afanas'ev, A. Z.; Ienkina, F. V.; Bundel', Yu. G.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1985 , vol. 21, # 4 p. 424 - 433
Khimiya Geterotsiklicheskikh Soedinenii, 1985 , vol. 21, # 4 p. 509 - 518
参考文献
Gromov, S. P.; Bkhaumik, M. M.; Bundel, Yu. G.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1987 , vol. 23, # 4 p. 406 - 414
Khimiya Geterotsiklicheskikh Soedinenii, 1987 , # 4 p. 488 - 496
反应条件
1: ethanolic KOH-solution 2: potassium ethylate / 360 °C View Scheme
参考文献
Marion; Oldfield
Canadian Journal of Research, Section B: Chemical Sciences, 1947 , vol. 25, p. 1,12
反应条件
Ambient temperature;
参考文献
Yurovskaya; Afanasyev; Maximova; Bundel
Tetrahedron, 1993 , vol. 49, # 22 p. 4945 - 4954
