1,5-二甲基-1H-吲哚合成路线 （共 9 条）
参考文献
Affinium Pharmaceuticals, Inc.
Patent: EP1226138 B1, 2004 ;
反应条件
1,4-diaza-bicyclo[2.2.2]octane; oxygen; copper(II) bis(trifluoromethanesulfonate) T=100°C; P=760.051 Torr;
参考文献
Wang, Yi-Feng; Zhang, Feng-Lian; Chiba, Shunsuke
Synthesis, 2012 , vol. 44, # 10 p. 1526 - 1534
反应条件
oxygen; copper dichloride in water; dimethyl sulfoxide T=120°C; 4 h;
参考文献
Chen, Jianbin; Liu, Bin; Liu, Dongfang; Liu, Shan; Cheng, Jiang
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 13 p. 2438 - 2442
反应条件
1: 5-methyl-1H-indole With tri[2-(2-methoxyethoxy)ethyl]amine; potassium tert-butylate in benzene
T=20°C; 2 h;
2: methyl iodide in benzene
T=20°C; 1 h;
参考文献
Diana, Patrizia; Carbone, Anna; Barraja, Paola; Kelter, Gerhard; Fiebig, Heinz-Herbert; Cirrincione, Girolamo
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 12 p. 4524 - 4529
反应条件
sodium methylate in methanol; oxalyl dichloride; water
参考文献
Zhang, Han-Cheng; Maryanoff, Bruce; Conway, Bruce; White, Kimberly; Ye, Hong; Hecker, Leonard Robert; McComsey, David F.
Patent: US2003/55097 A1, 2003 ;
US 20030055097 A1
反应条件
in benzene
1 h; Heating;
参考文献
Baudin, Jean-Bernard; Commenil, Marie-Gabrielle; Julia, Sylvestre A.; Lorne, Robert; Mauclaire, Laurent
Bulletin de la Societe Chimique de France, 1996 , vol. 133, # 4 p. 329 - 350
反应条件
1: Heating
2: 84 percent / BH3*THF / tetrahydrofuran / 1 h / Ambient temperature
View Scheme
参考文献
Pinto, Angelo C.; Silva, Filipe Soares Q. da; Silva, Rosangela B. da
Tetrahedron Letters, 1994 , vol. 35, # 48 p. 8923 - 8926
反应条件
potassium ethanolate
T=360°C;
参考文献
Marion; Oldfield
Canadian Journal of Research, Section B: Chemical Sciences, 1947 , vol. 25, p. 1,12
反应条件
1: ethanolic KOH-solution
2: potassium ethylate / 360 °C
View Scheme
参考文献
Marion; Oldfield
Canadian Journal of Research, Section B: Chemical Sciences, 1947 , vol. 25, p. 1,12
