4-氨基-5-噻唑甲酸甲酯合成路线 （共 4 条）
反应条件
hydrogen; nickel in ethanol; water P=2327.23 Torr; 168 h;
参考文献
MERCK SHARP and DOHME LIMITED; HOLLINGWORTH, Gregory, John; JONES, A., Brian; SPAREY, Timothy, Jason
Patent: WO2005/49613 A1, 2005 ;
Location in patent: Page/Page column 42 ;
WO 2005/049613 A1
反应条件
sodium tetrahydroborate in tetrahydrofuran; methanol T=20°C; 50 h;
参考文献
Eisai RandD Management Co., Ltd.
Patent: US2009/270433 A1, 2009 ;
Location in patent: Page/Page column 27 ;
反应条件
hydrogenchloride; zinc in methanol; water 1.5 h;
参考文献
BAYER PHARMACEUTICALS CORPORATION
Patent: WO2006/96338 A1, 2006 ;
Location in patent: Page/Page column 30-31 ;
反应条件
sodium hydride in tetrahydrofuran T=20°C; Condensation; 12 h;
参考文献
Dridi, Khaireddine; El Efrit, Mohamed Lotfi; Zantour, Hedi
Phosphorus, Sulfur and Silicon and Related Elements, 1998 , vol. 134-135, p. 407 - 412
