beta-D-5-脱氧呋喃木糖三乙酸酯合成路线 （共 28 条）
反应条件
1: With triethylamine in toluene T=15 - 17°C; Industry scale; 2: With 4-(N,N-dimethlyamino)pyridine in toluene 1.5 h; Industry scale;
参考文献
Behringer, Martin; Junghans, Bernd; Knipp, Bernhard; Pfeil, Bernhard; Zieres, Gerald
Patent: US2010/190976 A1, 2010 ;
Location in patent: Page/Page column 3 ;
反应条件
hydrogen; sodium carbonate; sponge nickel in isopropyl alcohol T=90°C; P=3750.38 Torr; 4 h; Product distribution / selectivity;
参考文献
API Corporation
Patent: EP2210896 A1, 2010 ;
Location in patent: Page/Page column 28 ;
反应条件
in hexane; isopropyl alcohol T=-10 - 5°C; 3 h; Purification / work up;
参考文献
HANMI PHARM. CO., LTD.
Patent: WO2008/105593 A1, 2008 ;
Location in patent: Page/Page column 11-12 ;
反应条件
pyridine; sulfuric acid in di-isopropyl ether T=0°C; 2 h; Cooling with ice; Product distribution / selectivity;
参考文献
API Corporation
Patent: EP2210896 A1, 2010 ;
Location in patent: Page/Page column 25 ;
反应条件
pyridine; sulfuric acid in anhydrous butyl ether T=20°C; 5 h; Cooling with ice; Product distribution / selectivity;
参考文献
API Corporation
Patent: EP2210896 A1, 2010 ;
Location in patent: Page/Page column 24 ;
反应条件
pyridine; 4-(N,N-dimethlyamino)pyridine Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
HANMI PHARM. CO., LTD.
Patent: WO2008/105593 A1, 2008 ;
Location in patent: Page/Page column 9-10 ;
反应条件
pyridine; 1H-imidazole T=20°C; 6 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2008/117047 A1, 2008 ;
Location in patent: Page/Page column 33-34 ;
WO 2008/117047 A1
反应条件
1: With acetic acid T=85°C; 2 h; 2: With pyridine; sulfuric acid; sodium acetate; acetic acid Product distribution / selectivity;
参考文献
API Corporation
Patent: EP2210896 A1, 2010 ;
Location in patent: Page/Page column 23 ;
反应条件
sulfuric acid in anhydrous butyl ether T=20°C; Cooling with ice; Product distribution / selectivity;
参考文献
API Corporation
Patent: EP2210896 A1, 2010 ;
Location in patent: Page/Page column 24 ;
参考文献
Kissman; Baker
Journal of the American Chemical Society, 1957 , vol. 79, p. 5534,5537
