3-氯吡嗪-2-羧酸甲酯合成路线 （共 12 条）
反应条件
1: 1.) aq. HCl, NaNO2, 2.) NaN3, aq. AcONa 2: 80 percent / SOCl2, DMF / toluene / 3 h / 80 °C View Scheme
参考文献
Holzer, Wolfgang; Eller, Gernot A.; Datterl, Barbara; Habicht, Daniela
Magnetic Resonance in Chemistry, 2009 , vol. 47, # 7 p. 617 - 624
反应条件
thionyl chloride; N,N-dimethyl-formamide in toluene T=80°C; 3 h;
参考文献
Okawa, Tomohiro; Eguchi, Shoji; Kakehi, Akikazu
Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 3 p. 247 - 254
反应条件
1: 1.) aq. NaNO2, H2SO4 / 1.) 10-16 deg C, 30 min, 2.) reflux, 30 min 2: 64 percent / HCl(gas) / 2.5 h / Heating 3: 48 percent / POCl3, 10N aq. HCl / 3 h / Heating View Scheme
参考文献
Krapcho, A. Paul; Gallagher, Cynthia E.; Hammach, Abdelhakim; Ellis, Michael; Menta, Ernesto; Oliva, Ambrogio
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 1 p. 27 - 32
反应条件
1: 64 percent / HCl(gas) / 2.5 h / Heating 2: 48 percent / POCl3, 10N aq. HCl / 3 h / Heating View Scheme
参考文献
Krapcho, A. Paul; Gallagher, Cynthia E.; Hammach, Abdelhakim; Ellis, Michael; Menta, Ernesto; Oliva, Ambrogio
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 1 p. 27 - 32
反应条件
trichlorophosphate 2 h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Sato, Nobuhiro
Journal of Chemical Research, Miniprint, 1984 , # 10 p. 2860 - 2875
反应条件
hydrogenchloride; sodium azide; sodium acetate; sodium nitrite Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Okawa, Tomohiro; Eguchi, Shoji; Kakehi, Akikazu
Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 3 p. 247 - 254
参考文献
Holzer, Wolfgang; Eller, Gernot A.; Datterl, Barbara; Habicht, Daniela
Magnetic Resonance in Chemistry, 2009 , vol. 47, # 7 p. 617 - 624
反应条件
bis-(2-hydroxy-ethyl)-amine; trichlorophosphate 2 h; Heating; Yield given. Yields of byproduct given;
参考文献
Sato, Nobuhiro; Fujii, Megumi
Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 5 p. 1177 - 1180
反应条件
water; sodium carbonate in methanol
参考文献
Magnetic Resonance in Chemistry, , vol. 47, # 7 p. 617 - 624
参考文献
Journal of the Chemical Society, , p. 1379,1380
