(4-甲基苯甲酰基)乙酸乙酯合成路线 （共 32 条）
反应条件
1: With sodium hydride in tetrahydrofuran Reflux; 2: With acetic acid in tetrahydrofuran
参考文献
Kumar, Satish; Namkung, Wan; Verkman; Sharma, Pawan K.
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 14 p. 4237 - 4244
反应条件
1: in tetrahydrofuran T=0 - 25°C; 46 h; 2: With hydrogenchloride in tetrahydrofuran; water T=20 - 25°C; 1 h;
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1471056 A1, 2004 ;
Location in patent: Page 44-45 ;
反应条件
yttria-stabilized zirconia in 1,2-dichloro-ethane 12 h; Heating;
参考文献
Jeyakumar, Kandasamy; Chand, Dillip Kumar
Synthesis, 2008 , # 11 p. 1685 - 1687
反应条件
1: ethyl acetoacetate With sodium hydride in tetrahydrofuran T=20°C; 0.666667 h; 2: 4-MeC6H4COBt in tetrahydrofuran T=20°C; 14 h; 3: With ammonium hydroxide; ammonium chloride in tetrahydrofuran; water 1 h; Heating;
参考文献
Katritzky, Alan R.; Wang, Zuoquan; Wang, Mingyi; Wilkerson, Chavon R.; Hall, C. Dennis; Akhmedov, Novruz G.
Journal of Organic Chemistry, 2004 , vol. 69, # 20 p. 6617 - 6622
反应条件
1: With lithium diisopropyl amide in tetrahydrofuran; n-heptane T=-78°C; 0.5 h; 2: With methanol in tetrahydrofuran T=-78 - 0°C; Further stages.;
参考文献
Galliford, Chris V.; Scheidt, Karl A.
Chemical Communications, 2008 , # 16 p. 1926 - 1928
反应条件
bis-triphenylphosphine-palladium(II) chloride in neat (no solvent) T=20°C; 2 h;
参考文献
Chen, Shufeng; Yuan, Fang; Zhao, Haiying; Li, Baoguo
RSC Advances, 2013 , vol. 3, # 31 p. 12616 - 12620
反应条件
triethylamine; magnesium chloride 1.) MeCN, 20 to 25 deg C, 2.5 h, 2.) 20 to 25 deg C, 12 h; Yield given. Multistep reaction;
参考文献
Merck and Co., Inc.
Patent: US6498165 B1, 2002 ;
US 6498165 B1
反应条件
sodium ethanolate T=0 - 5°C;
参考文献
Zhu, Youquan; Zou, Xiaomao; Hu, Fangzhong; Yao, Changsheng; Liu, Bin; Yang, Huazheng
Journal of Agricultural and Food Chemistry, 2005 , vol. 53, # 24 p. 9566 - 9570
反应条件
zinc in tetrahydrofuran 1) 30 deg C, 2 h, 2) reflux, 18 h;
参考文献
Kashima, Choji; Huang, Xin Cheng; Harada, Yukari; Hosomi, Akira
Journal of Organic Chemistry, 1993 , vol. 58, # 3 p. 793 - 794
反应条件
1: 4-methyl-benzoic acid With 1,1'-carbonyldiimidazole in tetrahydrofuran Acylation; 2: malonic acid ethyl ester monopotassium salt With magnesium chloride in tetrahydrofuran Substitution; decarboxylation;
参考文献
Jae; Winn; Von Geldern; Sorensen; Chiou; Nguyen; Marsh; Opgenorth
Journal of Medicinal Chemistry, 2001 , vol. 44, # 23 p. 3978 - 3984
