(4-甲基苯甲酰基)乙酸乙酯合成路线 （共 32 条）
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 60 °C / |Inert atmosphere
2.1: sodium hydride / mineral oil; toluene / 1.5 h / 85 °C
2.2: 2 h / 0 °C
3.1: copper (I) cyanide / diethyl ether / 0.5 h / -50 °C / |Inert atmosphere
3.2: 0.5 h / -50 °C / |Inert atmosphere
View Scheme
参考文献
Jolit, Anais; Walleser, Patrick M.; Yap, Glenn P. A.; Tius, Marcus A.
Angewandte Chemie - International Edition, 2014 , vol. 53, # 24 p. 6180 - 6183
Angew. Chem., 2014 , vol. 126, # 24 p. 6294 - 6297
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 60 °C / |Inert atmosphere
2.1: sodium hydride / mineral oil; toluene / 1.5 h / 85 °C
2.2: 2 h / 0 °C
3.1: copper (I) cyanide / diethyl ether / 0.5 h / -50 °C / |Inert atmosphere
3.2: 0.5 h / -50 °C / |Inert atmosphere
4.1: lithium hydroxide hydrate; water / tetrahydrofuran; methanol / 20 - 70 °C
View Scheme
参考文献
Jolit, Anais; Walleser, Patrick M.; Yap, Glenn P. A.; Tius, Marcus A.
Angewandte Chemie - International Edition, 2014 , vol. 53, # 24 p. 6180 - 6183
Angew. Chem., 2014 , vol. 126, # 24 p. 6294 - 6297
