(S)-1-(2-吡啶基)乙胺合成路线 （共 20 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol Reduction;
参考文献
Uenishi, Jun'ichi; Hiraoka, Takao; Yuyama, Kyoko; Yonemitsu, Osamu
Heterocycles, 2000 , vol. 52, # 2 p. 719 - 732
反应条件
borane-THF; triethyl borane; 1-[([1,3,2]dioxaborolan-2-yloxy)-diphenyl-methyl]-2-methylpropylamine in 1,4-dioxane T=10°C; 72 h; Product distribution / selectivity;
参考文献
OFFICE OF INTELLECTUAL PROPERTY AND TECHNOLOGY
Patent: WO2008/27740 A2, 2008 ;
Location in patent: Page/Page column 14-15 ;
反应条件
borane-THF; 1-[([1,3,2]dioxaborolan-2-yloxy)-diphenyl-methyl]-2-methylpropylamine in 1,4-dioxane T=10°C; 72 h; Product distribution / selectivity;
参考文献
OFFICE OF INTELLECTUAL PROPERTY AND TECHNOLOGY
Patent: WO2008/27740 A2, 2008 ;
Location in patent: Page/Page column 14-15 ;
反应条件
1: NaN3 2: H2 / Pd/C View Scheme
参考文献
Okabe, Akihiro; Ito, Akinori; Okumura, Kazuo; Shin, Chung-Gi
Chemistry Letters, 2001 , # 5 p. 380 - 381
反应条件
1: 43 percent / Ti(OEt)4 / CH2Cl2 / 14 h / 40 °C 2: 50 percent / 9-borabicyclo[3.3.1]nonane / tetrahydrofuran / 11 h / 25 °C 3: aq. HCl / methanol / 20 °C View Scheme
参考文献
Shin, Chung-Gi; Okabe, Akihiro; Ito, Akinori; Ito, Akio; Yonezawa, Yasuchika
Bulletin of the Chemical Society of Japan, 2002 , vol. 75, # 7 p. 1583 - 1596
反应条件
1: Et3N / CHCl3 / 0.5 h / 0 °C 2: 166 mg / NaN3 / dimethylformamide / 20 °C 3: H2 / 10 percent Pd-C / ethanol / 0.5 h / 20 °C View Scheme
参考文献
Uenishi, Jun'ichi; Hiraoka, Takao; Yuyama, Kyoko; Yonemitsu, Osamu
Heterocycles, 2000 , vol. 52, # 2 p. 719 - 732
反应条件
1: With acetic acid; zinc in ethanol T=20°C; 72 h; 2: With (2S,3S)-2,3-dihydroxybutanedioic acid in ethanol; water T=20°C; 4 h; 3: With potassium hydroxide
参考文献
Brunner, Henri; Niemetz, Markus
Monatshefte fur Chemie, 2002 , vol. 133, # 2 p. 115 - 126
反应条件
Pseudomonas cepacia lipase PSL-C in various solvent(s) T=30°C; 32 h; Enzymatic reaction;
参考文献
Torre, Oliver; Busto, Eduardo; Gotor-Fernandez, Vicente; Gotor, Vicente
Advanced Synthesis and Catalysis, 2007 , vol. 349, # 8-9 p. 1481 - 1488
反应条件
1: 10percent aq. HCl / 5 h / Ambient temperature 2: Et3N, 4-(dimethylamino)pyridine / CH2Cl2 / 24 h / Ambient temperature 3: NaN3 / dimethylformamide / 24 h / Ambient temperature 4: 95 percent / H2 / 10percent Pd/C / methanol / 24 h / 760 Torr / Ambient temperature View Scheme
参考文献
Chelucci, Giorgio; Cabras, M. Antonietta; Saba, Antonio
Tetrahedron: Asymmetry, 1994 , vol. 5, # 10 p. 1973 - 1978
反应条件
1: With diisobutylaluminium hydride in tetrahydrofuran T=-78°C; 6 h; 2: With trifluoroacetic acid in methanol T=20°C; 6 h; Title compound not separated from byproducts;
参考文献
Chelucci, Giorgio; Baldino, Salvatore; Solinas, Rosanna; Baratta, Walter
Tetrahedron Letters, 2005 , vol. 46, # 33 p. 5555 - 5558
