2-氯-4-[[3-(2,6-二氯苯基)-5-(1-甲基乙基)-4-异噁唑]甲氧基]-苯甲醛合成路线 (共 7 条)
反应条件
di-isopropyl azodicarboxylate; thiamine diphosphate in dichloromethane T=20°C; Mitsunobu reaction; 4 h;
参考文献
SmithKline Beecham Corporation
Patent: US6639078 B1, 2003 ;
Location in patent: Page/Page column 15 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 3 h;
参考文献
Misawa, Takashi; Hayashi, Hisamitsu; Sugiyama, Yuichi; Hashimoto, Yuichi
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 9 p. 2940 - 2949
反应条件
potassium carbonate; sodium iodide in acetone 5 h; Heating / reflux;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2004/48349 A1, 2004 ;
Location in patent: Page 88 ;
WO 2004/048349 A1
反应条件
1: 93 percent / DIBAL-H / tetrahydrofuran / 16 h / 20 °C 2: 63 percent / TPP; DIAD / CH2Cl2 / 4 h / 20 °C View Scheme
参考文献
Tognolini, Massimiliano; Incerti, Matteo; Pala, Daniele; Russo, Simonetta; Castelli, Riccardo; Hassan-Mohamed, Iftiin; Giorgio, Carmine; Lodola, Alessio
ChemMedChem, 2014 , vol. 9, # 1 p. 67 - 72
反应条件
1.1: NCS / dimethylformamide / 1 h / 20 °C 1.2: 3.1 g / NaOMe / tetrahydrofuran; methanol / 16 h / 20 °C 2.1: 93 percent / DIBAL-H / tetrahydrofuran / 16 h / 20 °C 3.1: 63 percent / TPP; DIAD / CH2Cl2 / 4 h / 20 °C View Scheme
参考文献
Maloney; Parks; Haffner; Fivush; Chandra; Plunket; Creech; Moore; Wilson; Lewis; Jones; Willson
Journal of Medicinal Chemistry, 2000 , vol. 43, # 16 p. 2971 - 2974
反应条件
1.1: 96 percent / OHNH2; NaOH / H2O; ethanol / 24 h / 90 °C 2.1: NCS / dimethylformamide / 1 h / 20 °C 2.2: 3.1 g / NaOMe / tetrahydrofuran; methanol / 16 h / 20 °C 3.1: 93 percent / DIBAL-H / tetrahydrofuran / 16 h / 20 °C 4.1: 63 percent / TPP; DIAD / CH2Cl2 / 4 h / 20 °C View Scheme
参考文献
Maloney; Parks; Haffner; Fivush; Chandra; Plunket; Creech; Moore; Wilson; Lewis; Jones; Willson
Journal of Medicinal Chemistry, 2000 , vol. 43, # 16 p. 2971 - 2974
反应条件
sodium hydride in tetrahydrofuran
T=20°C; Horner-Emmons reaction; 5 h;
参考文献
SmithKline Beecham Corporation
Patent: US6639078 B1, 2003 ;
Location in patent: Page/Page column 16 ;