(S)-(-)-乳酸甲酯合成路线 （共 55 条）
反应条件
Birman's catalyst; trimethylacetic anhydride; N-ethyl-N,N-diisopropylamine in diethyl ether T=20°C; 12 h; Inert atmosphereResolution of racemate; optical yield given as percent eeenantioselective reaction;
参考文献
Tokyo University of Science Educational Foundation Administrative Organization
Patent: US2011/319650 A1, 2011 ;
Location in patent: Page/Page column 11 ;
反应条件
lt;polystyrene-CH2-cinchonine(1+)gt;2lt;Pt15(CO)30gt;; hydrogen in methanol T=25°C; P=25857.4 Torr; 4 h; other keto esters; var. polystyrene-supported platinum and ruthenium catalysts; enantioselective hydrogenation;
参考文献
Simons, K. E.; Meheux, P. A.; Griffiths, S. P.; Sutherland, I. M.; Johnston, P.; et al.
Recueil des Travaux Chimiques des Pays-Bas, 1994 , vol. 113, # 10 p. 465 - 474
反应条件
[Mg(tbpca)2] in dichloromethane T=25°C; 6 h; Inert atmosphere; chemoselective reaction;
参考文献
Grala, Agnieszka; Ejfler, Jolanta; Jerzykiewicz, Lucjan B.; Sobota, Piotr
Dalton Transactions, 2011 , vol. 40, # 16 p. 4042 - 4044
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal in methanol
参考文献
Mislow,K. et al.
Journal of the American Chemical Society, 1962 , vol. 84, p. 1940 - 1944
反应条件
sodium hydrogencarbonate T=90 - 110°C; P=40 - 100 Torr; Heating / reflux; Purification / work up;
参考文献
COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH
Patent: WO2007/10548 A1, 2007 ;
Location in patent: Page/Page column 20-21 ;
反应条件
in diethyl ether T=0°C;
参考文献
Prosyanik; Mishchenko; Zelenskaya; Forni; Moretti; Torre; Bruekner; Malpezzi; Kostyanovsky
Russian Chemical Bulletin, 1998 , vol. 47, # 7 p. 1359 - 1364
反应条件
[Mg(tbpca)2] in dichloromethane T=25°C; 0.08 h; Inert atmosphere; chemoselective reaction;
参考文献
Grala, Agnieszka; Ejfler, Jolanta; Jerzykiewicz, Lucjan B.; Sobota, Piotr
Dalton Transactions, 2011 , vol. 40, # 16 p. 4042 - 4044
反应条件
thionyl chloride 2 h; Heating;
参考文献
Pitt, Nigel; Gani, David
Tetrahedron Letters, 1999 , vol. 40, # 19 p. 3811 - 3814
反应条件
in helium T=80°C; P=750.075 Torr; Chirasil-DEX CB; Resolution of racemateGas phase; Product distribution / selectivity;
参考文献
Costa, Nuno; Matos, Sara; Da Silva, Marco D. R. Gomes; Pereira, M. Manuela A.
ChemPlusChem, 2013 , vol. 78, # 12 p. 1466 - 1474
反应条件
toluene-4-sulfonic acid in methanol
参考文献
Mislow,K. et al.
Journal of the American Chemical Society, 1962 , vol. 84, p. 1940 - 1944
