1-Boc-3-甲基哌啶-3-甲酸乙酯合成路线 （共 7 条）
反应条件
1: With lithium diisopropyl amide in tetrahydrofuran T=-78 - 20°C; 2: With water; ammonium chloride in tetrahydrofuran T=0°C;
参考文献
SCHERING CORPORATION
Patent: WO2008/156614 A2, 2008 ;
Location in patent: Page/Page column 203 ;
WO 2008/156614 A2
反应条件
1: ethyl (S)-1-[(tert-butoxy)carbonyl]piperidine-3-carboxylate With lithium diisopropyl amide in tetrahydrofuran 2: methyl iodide in tetrahydrofuran
参考文献
SCHERING CORPORATION
Patent: EP1140904 B1, 2005 ;
Location in patent: Page/Page column 141 ;
反应条件
methyl iodide in tetrahydrofuran
参考文献
Bayer Aktiengesellschaft
Patent: US6562811 B1, 2003 ;
反应条件
1.1: LDA / tetrahydrofuran / -78 °C 1.2: 90 percent / tetrahydrofuran View Scheme
参考文献
Coppola, Gary M; Damon, Robert E; Eskesen, J Bruce; France, Dennis S; Paterniti Jr., James R
Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 17 p. 2439 - 2442
反应条件
1.1: LDA / tetrahydrofuran / -78 °C 1.2: 90 percent / tetrahydrofuran View Scheme
参考文献
Coppola, Gary M; Damon, Robert E; Eskesen, J Bruce; France, Dennis S; Paterniti Jr., James R
Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 17 p. 2439 - 2442
反应条件
trifluoroacetic acid
参考文献
Coppola, Gary M; Damon, Robert E; Eskesen, J Bruce; France, Dennis S; Paterniti Jr., James R
Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 17 p. 2439 - 2442
反应条件
1: With lithium triethylborohydride in tetrahydrofuran
T=20°C; 0.5 h;
2: With water; ammonium chloride in tetrahydrofuran
参考文献
SCHERING CORPORATION
Patent: WO2008/156614 A2, 2008 ;
Location in patent: Page/Page column 203 ;
WO 2008/156614 A2
