2-氨基-3,5-二氯苯甲酸合成路线 （共 38 条）
反应条件
hydrogenchloride; sodium nitrite
anschliessend Erwaermen mit SO2;
参考文献
Gevaert Photo-Prod. N. V.
Patent: US2673801 , 1949 ;
反应条件
hydrogenchloride; sodium azide; sodium acetate; sodium nitrite
1.) water, <5 deg C, 2.) 15 min; Yield given. Multistep reaction;
参考文献
Ardakani, Manouchehr Azadi; Smalley, Robert K.; Smith, Richard H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 10 p. 2501 - 2506
反应条件
1: 1.) NaNO2, conc. HCl, 2.) NaN3, NaOAc / 1.) water, <5 deg C, 2.) 15 min
2: SOCl2 / 2 h / Heating
3: pyridine / 0.5 h / Ambient temperature
View Scheme
参考文献
Ardakani, Manouchehr Azadi; Smalley, Robert K.; Smith, Richard H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 10 p. 2501 - 2506
反应条件
1: 1.) NaNO2, conc. HCl, 2.) NaN3, NaOAc / 1.) water, <5 deg C, 2.) 15 min
2: SOCl2 / 2 h / Heating
3: pyridine / 0.5 h / Ambient temperature
4: 67 percent / SOCl2 / Heating
View Scheme
参考文献
Ardakani, Manouchehr Azadi; Smalley, Robert K.; Smith, Richard H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 10 p. 2501 - 2506
反应条件
1: 1. NaNO2, aq. HCl 2. KI, aq. / 1.) 0 deg C, 30 min 2.) 50 deg C, 30 min; 100 deg C, 2 h
2: 78 percent / K2CO3, CuCl / dimethylformamide / 4 h / 140 °C
3: 87 percent / LiAlH4 / diethyl ether / 2.5 h / Heating
4: 96 percent / SOCl2 / benzene / 1.) 25 deg C, 20 min 2.) 60 deg C, 1 h 3.) reflux 1.5 h
5: KI / acetone / 5 h / Heating
6: LiAlH4 / diethyl ether / 2.5 h / Heating
View Scheme
参考文献
Valenta; Dlabac; Protiva
Collection of Czechoslovak Chemical Communications, 1981 , vol. 46, # 3 p. 781 - 791
反应条件
1: 1. NaNO2, aq. HCl 2. KI, aq. / 1.) 0 deg C, 30 min 2.) 50 deg C, 30 min; 100 deg C, 2 h
2: 78 percent / K2CO3, CuCl / dimethylformamide / 4 h / 140 °C
3: 87 percent / LiAlH4 / diethyl ether / 2.5 h / Heating
4: 96 percent / SOCl2 / benzene / 1.) 25 deg C, 20 min 2.) 60 deg C, 1 h 3.) reflux 1.5 h
5: 50 percent / dimethylformamide / 2 h / 35 °C
6: 98 percent / KOH / ethanol; H2O / 3 h / Heating
View Scheme
参考文献
Valenta; Dlabac; Protiva
Collection of Czechoslovak Chemical Communications, 1981 , vol. 46, # 3 p. 781 - 791
反应条件
water; copper; potassium carbonate
Erwaermen des Reaktionsprodukts mit ClSO3H;
参考文献
Joshi et al.
Proceedings - Indian Academy of Sciences, Section A, 1950 , # 32 p. 201,206, 208
反应条件
1: 1 h / 200 °C
2: POCl3; N,N-dimethylaniline / 16 h / Heating
View Scheme
参考文献
BASF
Patent: DE931845 , 1952 ;
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BASF
Patent: US2697097 , 1953 ;
