2-氮杂-双环[2,2,1]庚烷合成路线 （共 6 条）
反应条件
lithium aluminium tetrahydride in diethyl ether 1) 20 deg C, 1 h, 2) reflux, 6 h;
参考文献
Heesing, Albert; Herdering, Wilhelm
Chemische Berichte, 1983 , vol. 116, # 3 p. 1081 - 1096
反应条件
1: 56 percent / 2) glac. acetic acid / CH2Cl2 / 1) 10 deg C, 3 h, 2) 20 deg C, 1 h 2: 97 percent / H2 / 10percent Pd/C / ethyl acetate / 20 °C / 2625.2 Torr 3: 71 percent / LiAlH4 / diethyl ether / 1) 20 deg C, 1 h, 2) reflux, 6 h View Scheme
参考文献
Heesing, Albert; Herdering, Wilhelm
Chemische Berichte, 1983 , vol. 116, # 3 p. 1081 - 1096
反应条件
1: 97 percent / H2 / 10percent Pd/C / ethyl acetate / 20 °C / 2625.2 Torr 2: 71 percent / LiAlH4 / diethyl ether / 1) 20 deg C, 1 h, 2) reflux, 6 h View Scheme
参考文献
Heesing, Albert; Herdering, Wilhelm
Chemische Berichte, 1983 , vol. 116, # 3 p. 1081 - 1096
反应条件
sodium hydroxide in methanol T=10°C; 0.5 h; Title compound not separated from byproducts;
参考文献
Heesing, Albert; Herdering, Wilhelm
Chemische Berichte, 1983 , vol. 116, # 3 p. 1081 - 1096
反应条件
1: 2: Alkaline aqueous solution;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/5914 A1, 2006 ;
Location in patent: Page/Page column 92 ;
WO 2006/005914 A1
参考文献
The Coca-Cola Company
Patent: US5225591 A1, 1993 ;
