4-[N,N-双(2-羟乙基)氨基]苯甲醛合成路线 （共 10 条）
反应条件
sodium carbonate in methanol; water 15 h; Ambient temperature;
参考文献
Le Bouder, Thomas; Massiot, Philippe; Le Bozec, Hubert
Tetrahedron Letters, 1998 , vol. 39, # 38 p. 6869 - 6872
反应条件
1: N-phenyl-N,N-di(2-hydroxyethyl)amine With triethylamine; acetyl chloride in tetrahydrofuran 2: N,N-dimethyl-formamide With trichlorophosphate T=70°C; Vilsmeyer-Haack formylation; 3: With sodium carbonate in methanol; water T=20°C;
参考文献
Bouder, Thomas Le; Viau, Lydie; Guegan, Jean-Paul; Maury, Olivier; Bozec, Hubert Le
European Journal of Organic Chemistry, 2002 , # 17 p. 3024 - 3033
反应条件
1: 99 percent / Et3N / tetrahydrofuran / 15 h / 35 °C 2: 1.) POCl3, 2.) AcONa / 1.) 70 deg C, 6 h, 2.) H2O, room temp., 1 h 3: 99 percent / Na2CO3 / methanol; H2O / 15 h / Ambient temperature View Scheme
参考文献
Gao, Fang; Liu, Jian; Peng, Huayong; Hu, Nvdan; Li, Hongru; Zhang, Shengtao
Journal of Fluorescence, 2010 , vol. 20, # 3 p. 703 - 712
反应条件
1: 1.) POCl3, 2.) AcONa / 1.) 70 deg C, 6 h, 2.) H2O, room temp., 1 h 2: 99 percent / Na2CO3 / methanol; H2O / 15 h / Ambient temperature View Scheme
参考文献
Ikeda, Takahiro; Tadaki, Yui; Funajima, Ryo; Tatewaki, Yoko; Okada, Shuji
Molecular Crystals and Liquid Crystals, 2011 , vol. 539, p. 482 - 487
反应条件
in ethanol 16 h; Heating;
参考文献
Sen, A. K.; Mukhopadhyay, Sankardeb
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 7 p. 642 - 645
反应条件
4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide in tetrahydrofuran T=20°C; 24 h;
参考文献
Qi, Xin; Jun, Eun Jin; Xu, Li; Kim, Sung-Jin; Hong, Jay Sung Joong; Yoon, Yeo Joon; Yoon, Juyoung
Journal of Organic Chemistry, 2006 , vol. 71, # 7 p. 2881 - 2884
反应条件
triethylamine in dichloromethane T=20°C; 6 h;
参考文献
Chiang, Chih-Chia; Mouscadet, Jean-Francois; Tsai, Hou-Jen; Liu, Chi-Tsan; Hsu, Ling-Yih
Chemical and Pharmaceutical Bulletin, 2007 , vol. 55, # 12 p. 1740 - 1743
反应条件
1: 4-lt;N,N-bis(2-hydroxyethyl)aminogt;benzaldehyde With sodium hydride in tetrahydrofuran; mineral oil
0.5 h; RefluxInert atmosphere;
2: triethylene glycol di-p-tosylate in tetrahydrofuran; mineral oil
T=70°C; 48 h; Inert atmosphere;
参考文献
Wu, Chia-Shing; Chen, Chiao-Pei; Chen, Yun
Journal of Polymer Science, Part A: Polymer Chemistry, 2013 , vol. 51, # 18 p. 3975 - 3984
反应条件
1: 4-lt;N,N-bis(2-hydroxyethyl)aminogt;benzaldehyde With sodium hydride in tetrahydrofuran; mineral oil
0.5 h; Inert atmosphereReflux;
2: tetraethylene glycol di-p-toluenesulfonate in tetrahydrofuran; mineral oil
T=70°C; 48 h; Inert atmosphere;
参考文献
Wu, Chia-Shing; Lu, Huai-An; Chen, Chiao-Pei; Guo, Tzung-Fang; Chen, Yun
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 9 p. 1430 - 1439
反应条件
1: 50 percent / piperidine / ethanol / 5 h / Heating
2: 68.2 percent / hydrazine hydrate, / raney Ni / aq. NaOH / 0.5 h / Ambient temperature
View Scheme
参考文献
Sen, A.K.; Mukhopadhyay, Sankardeb
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 9 p. 939 - 941
