1: thionyl chloride / benzene / 2.5 h / Heating
2: NH3 / dioxane / 2 h / Ambient temperature
3: P2O5 / toluene / 1.) reflux, 2 h, 2.) RT, 16 h
View Scheme
参考文献
Chapleo, Christopher B.; Myers, Peter L.; Butler, Richard C. M.; Davis, John A.; Doxey, John C.; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 570 - 576