1: With n-butyllithium in tetrahydrofuran; hexanes T=-78 - -40°C; 0.5 h; 2: With tri-isopropoxy-borane in tetrahydrofuran; hexanes T=20°C; 3: With hydrogenchloride; potassium hydroxide more than 3 stages;
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/9086 A1, 2004 ;
Location in patent: Page/Page column 74-75 ;
WO 2004/009086 A1