1: 4-bromo-1-ethoxy-2-fluoro-benzene With n-butyllithium in tetrahydrofuran T=-70°C; 2 h; Inert atmosphere; 2: boric acid trimethyl ester in tetrahydrofuran T=-70 - 20°C; 16 h; 3: With hydrogenchloride in tetrahydrofuran; water

1: With magnesium in tetrahydrofuran T=40 - 60°C; 1 h; Heating / reflux; 2: With boric acid trimethyl ester in tetrahydrofuran T=-70 - 20°C; 24 h; 3: With hydrogenchloride in tetrahydrofuran; water T=5°C;

1.1: sodium hydroxide; tetrabutylammomium bromide / water / 6 h / 80 °C / Inert atmosphere 2.1: n-butyllithium / tetrahydrofuran / 2 h / -70 °C / Inert atmosphere 2.2: 16 h / -70 - 20 °C View Scheme

dihydrogen peroxide in tetrahydrofuran; water T=20 - 35°C; 24 h;